Enabling high-performance all-solid-state hybrid-ion batteries with a PEO-based electrolyte.

All-solid-state hybrid-ion batteries exhibiting a synergistic Na/Li de/intercalation mechanism were designed and assembled, by using modified PEO-based solid polymer electrolyte, NaV(PO)OF cathode, and Li metal anode. The batteries exhibited a high average working voltage of 3.88 V, and an energy density of 432.

Ferroptosis Regulator Modification Patterns and Tumor Microenvironment Immune Infiltration Characterization in Hepatocellular Carcinoma.

Accumulating studies have highlighted the biologic significances of ferroptosis modification in tumor progression, but little is known whether ferroptosis modification patterns have potential roles in tumor microenvironment (TME) immune cell infiltration of hepatocellular carcinoma (HCC). In this study, we evaluated 51 ferroptosis regulators and performed consensus clustering algorithm to determine ferroptosis modification patterns and the ferroptosis related gene signature in HCC. Gene set variation analysis (GSVA) was employed to explore biological molecular variations in distinct ferroptosis modification patterns.

Active targeted Janus nanoparticles enable anti-angiogenic drug combining chemotherapy agent to prevent postoperative hepatocellular carcinoma recurrence.

Surgery is one of the main effective strategies for the treatment of solid tumors, but high postoperative recurrence is also the main cause of death in current cancer therapy. The prevention of postoperative hepatocellular carcinoma (HCC) recurrence is a clinical problem that needs to be solved urgently. At present, there are still some problems to be solved, such as, how to achieve free drugs to target the site of surgical resection; develop a strategy for the simultaneous administration of multiple drugs to inhibit postoperative recurrence; and provide the appropriate animal model that mimics the process of postoperative HCC recurrence.

Efficacy and Side Effects of Combined Capecitabine Plus Intensity Modulated Radiotherapy as an Effective Adjuvant Therapy for Gastric Cancers.

This study aims to evaluate the clinical outcomes and the toxicities associated with intensity modulated radiotherapy (IMRT) administered in combination with capecitabine for gastric cancer. This study was conducted between July 2009 and October 2011, and included 31 patients (23 female and eight male patients; mean age: 57 years old) with pathologically confirmed gastric cancer (pathological staging T3 or T4 or positive lymph node). All patients underwent D2 surgery and adjuvant chemoradiotherapy, followed by combined treatment with IMRT and capecitabine.

Factors associated with decreased bone mineral density in postmenopausal women with schizophrenia.

Objective: This study examined the risk factors for decreased bone mineral density (BMD) in postmenopausal women with schizophrenia.

Methods: Cluster sampling method was adopted in this large-sample, cross-sectional study. A total of 219 postmenopausal female inpatients with schizophrenia were selected and interviewed in Beijing.

Self-assembled arrays of polyoxometalate-based metal-organic nanotubes for proton conduction and magnetism.

The first polyoxometalate-based metal-organic nanotube constructed via covalent bonds has been synthesized. POM anions stick the metal-organic nanotubes to build 3D nanotubular arrays. The stability, magnetic and proton conducting properties are investigated.

Redox-controlled δ-Dawson {Mn2(III)W17} polyoxometalate with photocatalytic H2 evolution activity.

A novel δ-Dawson [(WO5)3W14Mn2(III)O44Cl2](12-) compound induced by the Jahn-Teller distortion of Mn(III) has been synthesized through utilizing {Mn12} as a reactant, which exhibits photocatalytic H2 evolution activity. Its electrochemical behavior and magnetic properties were investigated.

Three cobalt(II)-linked {P8W48} network assemblies: syntheses, structures, and magnetic and photocatalysis properties.

Three cobalt(II)-containing tungstophosphate compounds, Na8Li8Co5[Co5.5(H2O)19P8W48.5O184]⋅60 H2O (1), K2Na4Li11Co5[Co7(H2O)28P8W48O184]Cl⋅ 59 H2O (2), and K2Na4LiCo11[Co8(H2O)32P8W48O184](CH3COO)4Cl⋅47 H2O (3), have been synthesized and characterized by IR spectroscopy, thermogravimetric analysis, elemental analyses, and magnetic measurements.

Zeolitic Imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle.

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

Chiral nanoporous metal-organic frameworks with high porosity as materials for drug delivery.

A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil.

A cationic iridium(III) complex showing aggregation-induced phosphorescent emission (AIPE) in the solid state: synthesis, characterization and properties.

We report the synthesis and characterization of two cationic iridium(III) complexes with dendritic carbazole ligands as ancillary ligands, namely, [Ir(ppy)(2)L3]PF(6) (1) and [Ir(ppy)(2)L4]PF(6) (2), where L3 and L4 represent 3,8-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)-1,10-phenanthroline and 3,8-bis(3',6'-di-tert-butyl-6-(3,6-di-tert-butyl-9H-carbazol-9-yl)-3,9'-bi(9H-carbazol)-9-yl)-1,10-phenanthroline, respectively. Their photophysical properties have been investigated and compared. The results have shown that complex 2 is aggregation-induced phosphorescent emission (AIPE) active and exhibits the highest photoluminescent quantum yield (PLQY) of 16.

Stepwise assembly of metal-organic framework based on a metal-organic polyhedron precursor for drug delivery.

A 12-connected network with fcu topology was firstly reported focusing on using predesigned metal-organic polyhedron (MOP) as the precursor, and its adsorption and delivery of the drug 5-fluorouracil (5-FU) was also determined.

Fluorescent hollow/rattle-type mesoporous Au@SiO2 nanocapsules for drug delivery and fluorescence imaging of cancer cells.

Multifunctional uniform and versatile hollow and rattle-type nanocapsules composed of spindle-shaped Au nanoparticles as cores and fluorescent mesoporous silica shells with tunable optical and fluorescent properties have been developed by controlled etching Au nanorods (AuNRs) coated with mesoporous SiO(2) (AuNR@mSiO(2)) via a small amount of aqua regia (volume ratio HCl/HNO(3)=3/1) as an etching agent in a facile way. The etching process can be tracked by UV-Vis absorption and fluorescence spectroscopy and the size of cavities in the hollow/rattle-type particles can be tuned by controlling the reaction time. The dye molecules incorporated in mSiO(2) walls enabled the nanocapsules to be utilized as a fluorescent imaging agent in cancer cell imaging.