Publications by authors named "Chun-Chie Wu"
Low immunogenicity in tumors and the immunosuppressive tumor microenvironment (TME) represent major obstacles to the full success of immunotherapy in cancer patients. A novel intratumoral xenogeneic tissue-specific cell immunotherapeutic approach could overcome the obstacles. Murine 4T1 triple negative breast cancer (TNBC) cells and Pan18 pancreatic ductal adenocarcinoma (PDAC) cells were used for establishing syngeneic graft tumor models to evaluate antitumor effect of intratumoral injection of xenogeneic tissue-specific cells.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors induce robust and durable responses in advanced bladder cancer (BC), but only for a subset of patients. Xenovaccination has been proposed as an effective immunotherapeutic approach to induce anti-tumor immunity. Thus, we proposed a novel intravesical xenogeneic urothelial cell immunotherapy strategy to treat advanced BC based on the hypothesis that implanted xenogeneic urothelial cells not only provoke xeno-rejection immune responses but also elicit bystander anti-tumor immunity.
View Article and Find Full Text PDFArticle Synopsis
- The urothelium, which lines the bladder and other urinary structures, relies on stem cells for maintenance and has potential for cell therapy to fix damage caused by various stresses, leading to conditions like cystitis.
- This study explores using porcine urothelial cells (PUCs) as a treatment for cystitis by introducing them directly into the bladder, showing that they can shield the urothelium from harmful chemical damage and reduce inflammation in a mouse model.
- Although PUC treatment was effective in maintaining the integrity of the bladder lining, it did trigger some immune responses, indicating a balance between potential benefits and the body’s reaction to foreign cells.