Bioinformatic Analysis Reveals both Oversampled and Underexplored Biosynthetic Diversity in Nonribosomal Peptides.

The traditional natural product discovery approach has accessed only a fraction of the chemical diversity in nature. The use of bioinformatic tools to interpret the instructions encoded in microbial biosynthetic genes has the potential to circumvent the existing methodological bottlenecks and greatly expand the scope of discovery. Structural prediction algorithms for nonribosomal peptides (NRPs), the largest family of microbial natural products, lie at the heart of this new approach.

Traffic and Environmental Cues and Slow-Down Behaviors in Virtual Driving.

This study used a driving simulator to investigate whether the presence of pedestrians and traffic engineering designs that reported to have reduction effects on overall traffic speed at intersections can facilitate drivers adopting lower impact speed behaviors at pedestrian crossings. Twenty-eight men (M age = 39.9 yr.

Differences in cognitive process-related skills between taxi and non-taxi drivers between 50 and 70 years old.

This study investigated differences between 50- to 70-yr.-old taxi and non-taxi drivers with respect to cognitive process-related skills. Psychological indicators associated with perceptuomotor, attentional, and spatial memory recall abilities were collected for 173 taxi drivers (7 women, 166 men; M age = 57.

The use of a quasi-naturalistic riding method to investigate bicyclists' behaviors when motorists pass.

The present study aimed to investigate how motorized vehicle-related factors, road-related factors, and bicyclist-related factors influenced motorists' decisions about initial passing distances and bicyclists' behaviors after the motorists started to pass. A quasi-naturalistic riding method was used for thirty-four participating bicyclists riding an instrumented bicycle in real traffic. The study included 1380 incidents of left-side passing by motorists and revealed that the factors studied influenced both the motorists' initial passing distance and the bicyclists' position (lateral distance from the passing motorists), wheel angle, and speed control behaviors while the motorists passed.

The use of mouse and one- and two-finger input methods for searching a large, horizontal display.

A horizontal, table-sized computer display was used to examine one- and two-finger search performances. 31 college students participated in a basic computer operation and target landmark search task. The mean completion times of the target landmark search task were analyzed by a repeated-measures analysis of variance with the following factors: input device, environmental familiarity, and cue.

Effect of visual-verbal load and spatial compatibility on stimulus response.

This study examined the effects of visual-verbalload (as measured by a visually presented reading-memory task with three levels) on a visual/auditory stimulus-response task. The three levels of load were defined as follows: "No Load" meant no other stimuli were presented concurrently; "Free Load" meant that a letter (A, B, C, or D) appeared at the same time as the visual or auditory stimulus; and "Force Load" was the same as "Free Load," but the participants were also instructed to count how many times the letter A appeared. The stimulus-response task also had three levels: "irrelevant," "compatible," and "incompatible" spatial conditions.

Measurement of auditory cues in drivers' distraction.

A driving simulator was used to examine the effects on driving performance of auditory cues in an in-vehicle information search task. Drivers' distraction by the search tasks was measured on a peripheral detection task. The difficulty of the search task was systematically varied to test the distraction caused by a quantified visual load.

Evidence for the selective attention mechanism and dual-task interference.

In order to explore the selective attention mechanism and the dual-task information-processing model, two experiments were carried out involving a visual search task and a visual detection task. The results showed that the early period of attention selection is controlled in a bottom-up manner. With respect to the dual-task information-processing model, the results showed that the central information-processing model would include a sequence model for tasks that use the same perception resource, causing a bottleneck in information processing.