Downregulation of Sustains the NF-B Pathway by Targeting during the Progression of Colorectal Cancer.

To investigate the role and the underlying mechanism of scaffold attachment factor B () in the progression of colorectal cancer (CRC). SAFB expression was analyzed in the Cancer Outlier Profile Analysis of Oncomine and in 175 paraffin-embedded archived CRC tissues. Gene Ontology analyses were performed to explore the mechanism of in CRC progression.

miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression.

The development and progression of CRC are regarded as a complicated network and progressive event including genetic and/or epigenetic alterations. Recent researches revealed that MicroRNAs are biomarkers and regulators of CRC progression. Analyses of published microarray datasets revealed that miR-450b-5p was highly up-regulated in CRC tissues.