Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.

Background: Hydrogen sulfide (HS) has been identified as the third gaseous signaling molecule. Endogenous HS plays a key role in the progression of various types of cancer. However, the effect of endogenous HS on the growth of esophageal cancer (EC) remains unknown.

Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.

Hydrogen sulfide (H S) has been widely recognized as one of gasotransmitters. Endogenous H S plays a crucial role in the progression of cancer. However, the effect of endogenous H S on the development of nasopharyngeal carcinoma (NPC) is still unknown.

Role of hydrogen sulphide in physiological and pathological angiogenesis.

The role of hydrogen sulphide (H S) in angiogenesis has been widely demonstrated. Vascular endothelial growth factor (VEGF) plays an important role in H S-induced angiogenesis. H S promotes angiogenesis by upregulating VEGF via pro-angiogenic signal transduction.

Cystathionine -Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.

Thyroid cancer is considered to be one of the most common endocrine tumors worldwide. Cystathionine -synthase (CBS) plays a crucial role in the occurrence of several types of malignancies. And yet, the mechanism of action of CBS in the growth of thyroid carcinoma cells is still unrevealed.

Long non-coding RNAs in Sus scrofa ileum under starvation stress.

Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research.

Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group.

The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases.

Hydrogen sulfide (HS) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. HS is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that HS plays an important role in cardiovascular homeostasis, and in most cases, HS has been reported to be downregulated in cardiovascular diseases (CVDs).

Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs.

Intestine contains the body's second largest genetic information, so a relatively stable microbiota ecosystems and interactions between intestinal micro-organisms play a pivotal role in the normal growth and development in animals. The establishment of intestinal microflora is affected by a variety of factors such as species, environmental factors, developmental stage, organizational structure and physiological characteristics of various parts of the digestive tract. Gene editing technology such as ZFN has recently been used as a new approach to replace the traditional transgenic technology and to make genetic modifications in animals.

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork.

Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats.