Publications by authors named "Chun-Bao Zang"
Cancer stem cells (CSCs) are considered the source of the initial tumor formation and postoperative recurrence and metastasis. CD133(+) cells in hepatocellular carcinoma (HCC) display cancer stem-like properties and are thought to be responsible for chemoradioresistance. To explore the functional role of CD133 in liver cancer stem cells (LCSCs), we isolated CD133(+) cells from the HCC cell line HepG2, which were tested and confirmed to be CSC-like cells in HCC, downregulated CD133 expression in HepG2-CD133(+) cells by lentivirus-mediated short hairpin (shRNA) and analyzed the effects of CD133 on the modulation of stemness properties and chemoradiosensitivity in LCSCs.
View Article and Find Full Text PDF[Preventive and therapeutic effects of xiaobanxia fuling decoction on cisplatin-induced pica rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2011
Article Synopsis
- The study aimed to evaluate the effects of Xiaobanxia Fuling Decoction (XBFD) on pica, an abnormal eating behavior, induced by cisplatin in rats, and to explore its underlying mechanisms.
- Forty-two male Sprague-Dawley rats were divided into seven groups to assess the impact of different doses of XBFD compared to a control group and a medication reference group.
- Results showed that XBFD significantly reduced kaolin consumption and improved food intake in the treatment groups, which related to lower expression levels of neurokinin 1 receptor in specific brain regions.