Why is it so clean under the apple trees: discovery of novel phloretin derivatives as potential herbicidal agents.

Background: Weeds are a serious problem in worldwide agricultural production. Natural products are a notable source for discovering new lead compounds. Phloretin is a dihydrochalcone compound which was discovered in 1835 and named after its concentrated content in roots, stems or bark of fruits.

Design, Synthesis, and Antifungal Activity of Melatonin Derivatives Containing a (Thio)Semicarbazide Group.

Melatonin is a natural hormone that has functions such as circadian rhythm regulation, neuroregulation and cardiac protection, as well as antifungal activity. In this study, two series of melatonin derivatives containing a semicarbazide or a thiosemicarbazide group were designed and synthesized. The antifungal screening results indicated that compound III-9 exhibited a broad antifungal spectrum against six phytopathogenic fungi at 50 µg/mL, with over 60% growth inhibition, and this is highlighted by its inhibition rates of 80.

Dual-Target Inhibitors─Discovery of Novel Diphenyl-(Thio)ether-Containing Benzoxaborole Derivatives as Potential Antifungal and Herbicidal Agents.

LeuRS and PPO are important targets in the development of green pesticides; novel diphenyl-(thio)ether-containing benzoxaborole derivatives were designed and synthesized as novel dual-target enzyme inhibitors; their antifungal activities against six kinds of common plant pathogens in vitro and their herbicidal activities against purslane and barnyard grass were studied. Most of the target compounds showed excellent antifungal activity against six kinds of plant pathogenic fungi in vitro, and this is highlighted by compounds and , both displayed 100.0% inhibition effects against three kinds of the tested plant pathogenic fungi under the concentrations of 50.