pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor.

Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP.

Towards breeding of rapeseed () with alien cytoplasm and powdery mildew resistance from Ethiopian mustard ().

Powdery mildew (PM), caused by , is an epidemic of oil rapeseed ( L.) growing worldwide, but PM resistant germplasm is rare in this species. We screened 102 accessions of and other cruciferous species and found an Ethiopian mustard () cultivar 'White flower' immune to PM in both the field and greenhouse.

Optimization of Ultrasonic Flavonoid Extraction from and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes.

(1) Background: Flavonoids are the primary medicinal ingredient of , which have significant antioxidant capacity. Optimizing the extraction of flavonoids (SIFs) and exploring the ability to block melanin deposition caused by reactive oxygen can greatly promote the development of whitening products. (2) Methods: Ultrasonic extraction process was optimized using the Box-Behnken design (BBD) and response surface methodology (RSM).

A new triterpenoid glucoside from .

A new triterpenoid glucoside, leuctriterpencoside (), along with two known compounds () were isolated from The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound showed significant inhibitory activity against α-glucosidase (IC value of 0.85 ± 0.

Optimization of Flavonoids Extraction Process in Stem Leaf and a Study of Antioxidant Activity and Its Effects on Mouse Melanoma B16 Cells.

The () stem leaf is rich in flavonoids. However, because of a lack of research on the flavonoid extraction process and functional development of stem leaf, these parts are discarded as agricultural wastes. Therefore, in this study, we intend to optimize the extraction process and develop the skin-whitening functions of stem leaf extracts.

iTRAQ-based proteomics screen for potential regulators of wheat (Triticum aestivum L.) root cell wall component response to Al stress.

Objective: The inhibition of Aluminum (Al)-induced root tip cell elongation is a major cause of plant root elongation suppression. The inhibition of root tip cell elongation is caused by a disruption of cell wall component metabolism, growth signaling, or cellular damage. The aim of this study was to identify the proteins involved in the metabolism of the root cell wall components under Al stress in the Al-tolerant wheat (Triticum aestivum L.

Eudesmanolides and Other Constituents from the Flowers of Wedelia trilobata.

Two eudesmane sesquiterpene lactones, wedetrilides B (1) and C (2), along with five known analogues (3 - 8), an ent-kaurane diterpenoid (9), a steroid (10), as well as cinnamic acid derivatives (11 - 13), were isolated from the flowers of Wedelia trilobata. Their structures were elucidated on the basis of extensive spectroscopic analyses and by comparison of their NMR data with those of related compounds. Furthermore, the structures of 1 and 3 - 5 were confirmed by X-ray single-crystal diffraction analyses.

A new isoflavone from the roots of Ficus auriculata.

A new isoflavone, 5,7,4'-trihydroxy-3'-hydroxymethylisoflavone (1), together with three known isoflavones, 3'-formyl-5,4'-dihydroxy-7-methoxyisoflavone (2), ficuisoflavone (3) and alpinumisoflavone (4), were isolated from the roots of Ficus auriculata. Among them, 1 is a rare isoflavone containing 16 carbon atoms on the carbon skeleton. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature.

2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells.

2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene (PYDDT) is a naturally occurring thiophene isolated from the roots of Echinops grijsii, a Chinese herbal medicine used to treat colon cancer, breast cancer, and lung cancer. There are many reports on the clinical use of Echinops grijsii alone or in combination with other herbs to treat malignant tumors. We previously reported that the expression and activity of phase II enzymes including GSTs and NQO1 could be induced through the activation of Keap1-Nrf2 pathway by the treatment of PYDDT.

Lactones from Ficus auriculata and their effects on the proliferation function of primary mouse osteoblasts in vitro.

Bioassay-guided fractionation of the petroleum ether, chloroform and EtOAc extracts of the stems of Ficus auriculata led to the isolation of five new 12-membered lactones (3R,4R)-4-hydroxy-de-O-methyllasiodiplodin (1), 6-oxolasiodiplodin (2) and ficusines A-C (3-5), together with three known related analogues (6-8). The structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configurations of 3 and 8 were established by single crystal X-ray diffraction analysis.

Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways.

Objective: Dracorhodin perchlorate (DP) was a synthetic analogue of the antimicrobial anthocyanin red pigment dracorhodin. It was reported that DP could induce apoptosis in human prostate cancer, human gastric tumor cells and human melanoma, but the cytotoxic effect of DP on human breast cancer was not investigated. This study would investigate whether DP was a candidate chemical of anti-human breast cancer.

[Fluorescence properties of municipal wastewater with industrial wastewater as major components].

The present paper studied fluorescence fingerprint properties of the municipal wastewater with industrial wastewater as major components. There existed three typical fluorescence peaks in the excitation-emission matrix of the municipal wastewater, locating at about lambda(ex)/lambda(em) of 275/310, 230/340 and 220/310 nm respectively. The wastewater didn't display typical protein-like fluorescence as the municipal wastewater with domestic sewage as major component.

[Numerical simulation on HHG spectra of two-electron H3(+) model].

The authors present a one-dimensional calculation model of H3(+), and the time-dependent wavefunction was obtained by the symmetric split-operator method. The authors investigated the high-order harmonic generation (HHG) properties of H3(+) model exposed to 800 nm-wavelength ultrashort laser pulse. The effect of electron interaction on the HHG spectra is less profound than at the cut-off frequency.

[3-D fluorescence properties of petrochemical wastewater].

Petrochemical wastewater is one of major types of industrial wastewater in China. It is of huge quantity and causes serious pollution. Wastewater contains lots of fluorescence matters.