Tranexamic acid dosage for spinal surgery: a meta-analysis.

Purpose: We conducted this meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of different doses of intravenous tranexamic acid (TXA) in spinal surgery.

Methods: We searched relevant academic articles from PubMed, Embase, the Cochrane Library, and CNKI. Two reviewers independently selected studies, assessed quality, extracted data, and evaluated the risk of bias.

[Effects of 1 Gene Antisense Oligonucleotides on Growth of Esophageal Cancer Cells].

Objective: To investigate the effect of antisense oligodeoxynucleotides (ASODN) of Homeobox A1 gene ( 1) on proliferation, apoptosis, invasion and migration of esophageal carcinoma cells.

Methods: The expression of HOXA1 protein in normal esophageal epithelial cells Het-1A and esophageal cancer TE-1, EC9706 and Eca109 cells was detected by Western blot. Screening of highly expressed of HOXA1 protein esophageal squamous cell carcinoma cells for follow-up experiments.

IL-16 regulates macrophage polarization as a target gene of mir-145-3p.

Background: Interleukin 16 is an immunomodulatory chemokine that signals through CD4 + T cells, monocytes, macrophages and dendritic cells. Its expression in immune-related cells enhances the antimicrobial effect and inhibits HIV replication in macrophages. However, the role of IL-16 in macrophage polarization is uncertain.

miR-10b promotes invasion by targeting KLF4 in osteosarcoma cells.

Objective: Osteosarcoma is a common malignancy with high rate of metastasis. miR-10b has been reported to be expressed in many types of tumors abnormally and be associated with cancer carcinogenesis and progression. But the function of miR-10b in osteosarcoma is still unknown.

Treatment of Gustilo grade III leg fractures by external fixation associated with limited internal fixation.

Objective: To explore the clinical effects of external fixation associated with limited internal fixation on treatment of Gustilo grade III leg fractures.

Methods: From July 2006 to December 2008, 40 cases of Gustilo grade III leg fractures were emergently treated in our unit with external fixation frames. Soft tissue injuries were grouped according to the Gustilo classification as IIIA in 17 cases, IIIB in 13 cases, and IIIC in 10 cases.

Multi-slice spiral CT 3-dimensional reconstruction technique to treat multi-segmental degenerative spinal stenosis with traumatic instability of lower cervical spine.

Objective: To study the feasibility of multi-slice spiral computed tomography (MSCT) 3-dimensional reconstruction technique in assisting cervical pedicle screw fixation (PSF) and double-door laminoplasty to treat multi-segmental degenerative spinal stenosis with traumatic instability (MDSTI) of lower cervical spine.

Methods: From September 2006 to August 2007, PSF combined with double-door laminoplasty was performed in 9 patients with MDSTI of lower cervical spine. MSCT 3-dimensional reconstruction techniques, including volume rendering (VR) and multi-planar reconstruction (MPR), were used to assist preoperative diagnosis and measurement to guide the procedure.

Gene expression profile related to inflammation in rat model of traumatic deep vein thrombosis.

Objective: To study the relationship between inflammation and traumatic deep vein thrombosis (TDVT).

Methods: A rat model of deep venous thrombosis was established by directly clamping femoral vein. Based on the different biological situations of femoral vein thrombosis and observation phases, 150 SD rats were divided into 7 groups.

Application of spiral CT image 3D reconstruction in severe talar neck fracture.

Objective: To explore the application of the spiral computerized tomography (CT) image three-dimensional (3D) reconstruction technique associated with the conventional radiography in the diagnosis and treatment of severe talar neck fracture.

Methods: Using the multi-slice spiral CT image 3D reconstruction technique, we analysed 11 cases of talar neck fracture. The fractures were reduced and fixed through a minimal incision and internal fixation with titanium cannulated lag screws.

Lower cervical spine injury treated with lateral mass plates and pedicle screws through posterior approach.

Objective: To treat injury of the lower cervical spine C6 to C7 with cervical lateral mass plates and T1 pedicle screws through posterior approach.

Methods: The data of 8 patients with lower cervical spine C6 or C7 injury (6 patients with fracture and dislocation in C6 and C7 and 2 with fracture in C7) were analyzed retrospectively in this study. For the preoperative American Spinal Injury Association (ASIA) classification, Grade C was found in 3 cases and Grade D in 5 cases.

[The use of lateral mass screws and pedicle screws for the treatment of injury of lower cervical spine].

Objective: To discuss the effect of the use of the cervical lateral mass plates screws and T(1) pedicle screws for the treatment of C(6) to C(7) injury through posterior approach.

Methods: There were 8 patients in the study group; Each of them had been injured with low cervical spine C(6) or C(7). There were 6 cases with C(6)-C(7) injury and 2 cases with C(7) injury.