Publications by authors named "Chun Mei Jiao"
Background: Targeting glucose uptake by glucose transporter (GLUT) inhibitors is a therapeutic opportunity, but efforts on GLUT inhibitors have not been successful in the clinic and the underlying mechanism remains unclear. We aim to identify the key metabolic changes responsible for cancer cell survival from glucose limitation and elucidate its mechanism.
Methods: The level of phosphorylated YAP was analyzed with Western blotting and Phos-tag immunoblotting.
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair.
Proc Natl Acad Sci U S A
July 2024
Article Synopsis
- - RNF168, an enzyme responsible for tagging proteins to aid DNA repair, was found to condense into clusters at DNA double-strand breaks (DSBs) through a process called liquid-liquid phase separation (LLPS), particularly when triggered by a specific type of polyubiquitin chain.
- - The study identified a specific region within RNF168 that is crucial for its condensation and showed that this process enhances its ability to mark H2A.X, a protein involved in DNA repair, indicating a cycle that boosts RNF168's activity and accumulation at DSBs.
- - When RNF168's ability to undergo LLPS is impaired, the recruitment of other important repair proteins like 53BP1 and BRCA
Article Synopsis
- The band offsets of non-polar A-plane GaN/AlN and AlN/GaN heterojunctions were measured using X-ray photoemission spectroscopy.
- A significant asymmetry was found between the forward and backward band offsets in these heterojunctions.
- The valence-band offsets were determined to be 1.33 ± 0.16 eV for GaN/AlN and 0.73 ± 0.16 eV for AlN/GaN, with a notable 0.6 eV difference attributed to piezoelectric strain effects in the non-polar layers.