Publications by authors named "Chun Ling Lei"
Effects of latanoprost on the expression of TGF-β1 and Wnt / β-catenin signaling pathway in the choroid of form-deprivation myopia rats.
Cell Mol Biol (Noisy-le-grand)
September 2020
Article Synopsis
- The study examined the impact of latanoprost on TGF-β1 expression and the Wnt/β-Catenin signaling pathway in choroid tissues of rats with form-deprivation myopia.
- Two groups of 20 rats were involved: a control group and an FDM model group treated with latanoprost for 28 days.
- Results indicated significant changes in ocular axis length and TGF-β1 levels between the FDM and control groups, with various proteins (like dcl3 and β-Catenin) showing altered expression patterns in the FDM model.
Aim: To report the surgical technique and efficacy of the tiled transplantation internal limiting membrane (ILM) pedicle flap technique after vitrectomy for 33 patients with large macular hole (MH).
Methods: This study was a prospective noncontrolled interventional study. All patients were treated by vitrectomy, the tiled transplantation ILM pedicle flap and gas tamponade.
Article Synopsis
- *Thirty-eight stroke patients were split into treatment and sham groups, receiving either active rTMS or pseudo-stimulations, and were assessed using specific tests and brain imaging before and after treatment.
- *Results showed that the continuous TBS group had the most significant improvements in symptoms and brain connectivity, suggesting it is the most effective rTMS method for rehabilitation in these patients.
Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration.
Invest Ophthalmol Vis Sci
August 2015
Purpose: Two common single nucleotide polymorphisms (SNPs) in the CX3CR1 gene, T280M and V249I, have been reported to affect the risk of age-related macular degeneration (AMD) in several studies. The aim of the present study was to combine all published data on the relationship between these two variants and AMD susceptibility in a meta-analysis to clarify this association.
Methods: MEDLINE, EMBASE, and ISI Web of Science were searched for all eligible studies on the relationship between AMD and T280M and V249I variants.
Objectives: In this study, we employed a rat model and examined the expression pattern of neuregulin-1 (NRG-1) in optic nerve and retinal ganglion cells (RGCs) in response to optic nerve injury to understand the role of NRG-1 in conferring protection against acute optic nerve injury.
Method: Forty-eight male rats were randomly divided into two groups, the sham-operation group (n=24) and optic nerve injury group (n=24). Flash visual evoked potentials (FVEP) and fundography images were acquired at different time points following optic nerve injury (2h, 1d, 2d, 7d, 14d and 28d).
Objective: The aim of this study was to identify the relationship between G1961E and D2177N variants in the ABCA4 gene with AMD susceptibility.
Design And Methods: All eligible studies published up to October 2014 were obtained from MEDLINE, EMBASE, and ISI Web of Science. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated to evaluate the strength of this association.
Aim: To describe clinical findings and complications from cases of traumatic lens subluxation/dislocation in patients with secondary glaucoma, and discuss the multiple treating methods of operation combined with primary intraocular lens (IOL) implantation.
Methods: Non-comparative retrospective observational case series.
Participants: 30 cases (30 eyes) of lens subluxation/dislocation in patients with secondary glaucoma were investigated which accepted the surgical treatment by author in the Ophthalmology of Xi'an No.
Objective: To investigate the regulatory effects of ninjurin-1 on adhesion of myeloid cells in the retina at the early stage of diabetic rats.
Methods: Experimental study. The rat diabetic model was induced by intraperitoneal injection of streptozotocin.
Aim: To explore the effect of alloxan time administerDrug on establishing diabetic rabbit model.
Methods: Thirty-six healthy rabbits, weighed 2-2.5kg, were randomly divided into one time administerDrug group (Group A, n=12), two times administerDrug group (Group B, n=12) and three times administerDrug group(Group C, n=12).