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Publications by authors named "Chun Ki Franklin Au"

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Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease.
Chun Ki Franklin Au Jill Abrigo Chunlei Liu Wanting Liu Jack Lee Lisa Wing Chi Au

J Magn Reson Imaging

June 2021

Background: The fimbria is a small white matter bundle that connects the hippocampus to the rest of the brain. Damage to the hippocampal gray matter is established in Alzheimer's disease (AD), but the hippocampal fimbrial status in the pathogenesis of AD is unclear. AD-related demyelination and iron deposition alter the diamagnetic and paramagnetic composition of tissues, which can be measured by quantitative susceptibility mapping (QSM).

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Synopsis of recent research by authors named "Chun Ki Franklin Au"

  • - Chun Ki Franklin Au's research focuses on the application of quantitative susceptibility mapping (QSM) techniques to investigate brain structures impacted by Alzheimer's disease, specifically targeting the hippocampal fimbria.
  • - His 2021 study highlights how changes in the fimbria— a crucial white matter region linking the hippocampus to the brain— can provide insights into the disease's pathogenesis, including demyelination and iron deposition.
  • - The findings suggest that measuring the changes in magnetic susceptibility of brain tissues via QSM could serve as a valuable tool for understanding the neurological underpinnings of Alzheimer's disease.

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