Publications by authors named "Chun Ju Chiang"
Background: The clinical outcomes of patients with anaplastic lymphoma kinase-positive (ALK+) advanced lung adenocarcinoma vary according to real-world data.
Objective: In this study, we aimed to investigate the treatment discontinuation (TTD) and overall survival (OS) of patients with ALK+ advanced lung adenocarcinoma treated with first-line ALK-TKIs in Taiwan.
Patients And Methods: This retrospective study evaluated all advanced lung adenocarcinoma patients registered in the National Taiwan Cancer Registry from 2017 to 2020 who had ALK rearrangement and received ALK-TKI treatment, using data from Taiwan's National Health Insurance Research Database (NHIRD).
Background: Colorectal cancer remains a major global public health challenge. Its incidence is shaped by a complex interplay of screening programmes and age, period and cohort factors.
Methods: We introduce a novel Age-Period-Cohort-Screening (APCS) model to analyse trends in colorectal cancer incidence in Taiwan from 2000 to 2019.
Objective: The aim of this study was to evaluate the efficacy of different treatment intensities (TIs) in patients with nasopharyngeal carcinoma (NPC).
Methods: The study assessed newly diagnosed, non-metastatic NPC patients from the Taiwan Cancer Registry between 2010 and 2017. TIs were divided into four groups: TI1 [radiotherapy (RT) alone or induction chemotherapy (IC) followed by RT); TI2 (concurrent chemoradiotherapy (CRT) alone); TI3 (IC followed by CRT or CRT followed by adjuvant chemotherapy (AC)]; and TI4 (IC followed by CRT followed by AC).
Article Synopsis
- Thyroid cancer rates have risen significantly among Taiwanese females, with age-adjusted rates increasing from 7.37 to 20.53 per 100,000 people between 1995-1999 and 2015-2019, respectively.
- The study found younger females showed the highest increase in incidence rates, particularly in the 50-54 age group, with a notable trend linked to later birth cohorts.
- Researchers suggested that overdiagnosis might largely explain this trend, alongside a significant negative correlation between thyroid cancer incidence and fertility rates, highlighting a need for further investigation into these relationships.
Predicting Lung Cancer Survival to the Future: Population-Based Cancer Survival Modeling Study.
JMIR Public Health Surveill
May 2024
Background: Lung cancer remains the leading cause of cancer-related mortality globally, with late diagnoses often resulting in poor prognosis. In response, the Lung Ambition Alliance aims to double the 5-year survival rate by 2025.
Objective: Using the Taiwan Cancer Registry, this study uses the survivorship-period-cohort model to assess the feasibility of achieving this goal by predicting future survival rates of patients with lung cancer in Taiwan.
Introduction: Colorectal cancer (CRC) remains a significant public health concern. This study aims to provide a comprehensive understanding of the effectiveness of fecal immunochemical test (FIT) screening on CRC incidence and mortality, leveraging the scale of over 1.5 million randomly selected Taiwanese and more than 11.
View Article and Find Full Text PDFContext: The association between colorectal cancer (CRC) and new-onset diabetes mellitus remains unclear.
Objective: To examine the association between CRC and the risk of subsequent diabetes mellitus and to further investigate the impact of chemotherapy on diabetes mellitus risk in CRC.
Design: A nationwide cohort study.
Background: The World Health Organization aims for the global elimination of cervical cancer, necessitating modeling studies to forecast long-term outcomes.
Objective: This paper introduces a macrosimulation framework using age-period-cohort modeling and population attributable fractions to predict the timeline for eliminating cervical cancer in Taiwan.
Methods: Data for cervical cancer cases from 1997 to 2016 were obtained from the Taiwan Cancer Registry.
Background: Fertility-sparing surgery (FSS) is an alternative choice of young patients who have not completed their family planning and still have fertility needs. The aims of this study were to compare the outcomes of early-stage epithelial ovarian cancer (EOC) patients undergoing FSS and radical comprehensive staging surgery (RCS), and the suitability of FSS.
Methods: A total of 1297 patients aged between 20 and 44 years with newly diagnosed early-stage EOC were recruited from the Taiwan Cancer Registry database between 2009 and 2017.
Background: The effects of long-term PM exposures since 1968 on adenocarcinoma lung cancer (AdLC) were not studied before.
Methods: This case-referent study used nationwide cancer registry data since 1997 and air pollution data since 1968 in Taiwan to estimate risks of 30-year PM exposures on AdLC. Cases were all AdLC, while references were all non-AdLC.
Background: Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence.
Methods: By using the Taiwan Cancer Registry dataset, we enrolled patients aged 40-84 diagnosed with arsenic-related cancers, including hepatocellular carcinoma, small and squamous cell lung cancer, Bowen's disease, basal and squamous cell skin cancer, urothelial bladder cancer, and upper tract urothelial carcinoma between 1995 and 2019.
Purpose: This study aims to raise awareness of the disparities in survival predictions among races in head and neck cancer (HNC) patients by developing and validating population-based prognostic models specifically tailored for Taiwanese and Asian populations.
Methods: A total of 49,137 patients diagnosed with HNCs were included from the Taiwan Cancer Registry (TCR). Six prognostic models, divided into three categories based on surgical status, were developed to predict both overall survival (OS) and cancer-specific survival using the registered demographic and clinicopathological characteristics in the Cox proportional hazards model.
Article Synopsis
- * Researchers followed breast cancer patients diagnosed between 2007 and 2016 in Taiwan and compared their health outcomes to a general population over time.
- * Findings revealed a higher CAD risk shortly after diagnosis but no link between radiotherapy and increased CAD or stroke risk.
Background: Although diabetes is a poor prognostic factor for colorectal cancer (CRC), whether diabetes severity provides an additional predictive value for CRC prognosis remains unclear. The study aimed to investigate the prognostic differences after curative CRC resection among patients with different diabetic severities.
Methods: This population-based retrospective cohort study analyzed data registered between 2007 and 2015 in the Cancer Registry Database, which is linked to the National Health Insurance Research Database and National Death Registry.
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries.
Methods: We used population-based cancer registry data to calculate 5-year relative survival (RS) for the oral cavity, hypopharynx, larynx, nasal cavity, and major salivary gland in Europe, Taiwan, and Japan.
Background: This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population.
Methods: We used the National Taiwan Cancer Registry Database to construct a cohort of patients with parathyroid cancer from January 1, 2004, to December 31, 2019. We compared the incidence of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, coronary heart disease, and heart failure with the general population matched based on a propensity score in a one-to-five fashion.
Article Synopsis
- The study examines how a family history of lung cancer affects screening for the disease using low-dose computed tomography (LDCT), following participants over multiple years.
- A total of 1,102 participants were enrolled, and the overall lung cancer detection rate was 4.5%, with higher rates observed in families with multiple lung cancer cases and among never-smokers.
- The findings suggest that having a maternal relative with lung cancer significantly increases the risk, highlighting the need for further research through randomized controlled trials to determine if LDCT screening can reduce mortality in this high-risk group.
Article Synopsis
- Taiwan has one of the highest rates of upper tract urothelial cancer (UTUC) in the world, especially among women, but there has been no comprehensive long-term study on this issue.
- A nationwide analysis of UTUC incidence from 1985 to 2019 used data from the Taiwan Cancer Registry, breaking down the population into nine age groups to assess age-specific trends.
- The findings revealed a notable increase in renal pelvis cancer incidence, with women experiencing a higher rise than men, particularly in older age groups and among younger cohorts compared to older ones.
Article Synopsis
- The study focuses on the impact of ALK fusion mutations in lung cancer, particularly assessing how smoking status and ALK-tyrosine kinase inhibitors (TKIs) affect overall survival in treatment-naïve advanced lung adenocarcinoma patients.
- The analysis included 9,575 advanced stage lung adenocarcinoma patients, revealing that 6.8% had ALK mutations, with never-smokers showing a significantly longer median overall survival (OS) compared to smokers when treated with first-line ALK-TKIs.
- The findings highlight the importance of ALK testing regardless of smoking status and suggest that smokers not receiving first-line ALK-TKIs experience worse outcomes, indicating a need for further research in this
Introduction: For patients with T2aN0 stage IB lung adenocarcinoma, benefits of adjuvant chemotherapy remain controversial. Here, we aimed to evaluate such benefits.
Methods: This retrospective cohort study was conducted on the database of the National Taiwan Cancer Registry.
Article Synopsis
- In Taiwan, high rates of cigarette smoking, betel chewing, and alcohol consumption have led to significant cancer deaths, particularly in the oral cavity and throat.
- Analysis from 1980 to 2019 showed strong links between these cancers and lifestyle factors, with a notable period effect from 1990 to 2009 related to betel nut consumption and an ongoing effect from HPV on oropharyngeal cancers.
- Government initiatives to reduce smoking and betel quid usage since the 1990s have successfully stabilized cancer rates, suggesting continued policy impact may lead to further declines in head and neck cancer incidence.