Publications by authors named "Chun Ho Szeto"
Article Synopsis
- Transient global amnesia (TGA) is a temporary memory condition often seen in older adults, marked by sudden memory loss that resolves within 24 hours while the person remains aware of their identity.
- A case study of a woman in her 60s illustrates how her acute memory problems were initially mistaken for a stroke after taking migraine and sleep medications, but were later correctly identified as TGA.
- This situation emphasizes the need to carefully distinguish TGA from other serious conditions to avoid unnecessary treatments and hospital costs, particularly since combining certain medications may increase the risk of TGA.
Spontaneous gastric intramural haematoma is an uncommon complication associated with anticoagulant therapy. A patient receiving chronic warfarin for paroxysmal atrial fibrillation was admitted due to atrial fibrillation with rapid ventricular response (RVR). An incidental intra-abdominal mass was detected on a CT scan.
View Article and Find Full Text PDFThe colorectal cancer (CRC) and polyps incidentally found in autopsies represent the lesions that have not actually caused problems throughout the lifetime and thus may not need to be removed during screening. This study aimed to investigate the prevalence of incidental CRC (iCRC) and polyps in autopsies of different populations. A systematic search was performed on 19 August 2022 to identify autopsy studies that provided data on prevalence of iCRC, adenomatous polyps, hyperplastic polyps, and/or all polyps combined.
View Article and Find Full Text PDFPontocerebellar hypoplasia type 1B (PCH1B) is an autosomal recessive neurodegenerative disorder that involves hypoplasia or atrophy of the cerebellum and pons. PCH1B is caused by mutations in , which encodes a subunit of the RNA exosome complex. The most frequently observed mutation in PCH1B patients is a c.
View Article and Find Full Text PDFLung cancer is worldwide the most common malignancy. Standard of care treatments for early-stage non-small-cell lung cancer (NSCLC) include surgery and adjuvant chemotherapy. However, these patients continue to have poor prognosis due to systemic or local relapse.
View Article and Find Full Text PDFArticle Synopsis
- A high-fat diet (HFD) has been linked to an increased risk of colorectal cancer (CRC), affecting gut microbiota and metabolites in mouse models.
- Mice on an HFD exhibited higher tumor formation, altered gut microbiota with an increase in harmful bacteria, and compromised gut barrier function compared to those on a control diet.
- The study suggests that the changes caused by an HFD, including shifts in gut microbiota and metabolite levels (like elevated lysophosphatidic acid), play a crucial role in driving the development of CRC.
Background And Aim: We have previously shown that fecal microbial markers might be useful for non-invasive diagnosis of colorectal cancer (CRC) and adenoma. Here, we assessed the application of microbial DNA markers, as compared with and in combination with fecal immunochemical test (FIT), in detecting CRC and adenoma in symptomatic patients and asymptomatic subjects.
Methods: We recruited 676 subjects [210 CRC, 115 advanced adenoma (AA), 86 non-advanced adenoma, and 265 non-neoplastic controls], including 241 symptomatic and 435 asymptomatic subjects.
Objective: is associated with gastric inflammation, precancerous gastric atrophy (GA) and intestinal metaplasia (IM). We aimed to identify microbes that are associated with progressive inflammation, GA and IM 1 year after eradication.
Design: A total of 587 -positive patients were randomised to receive eradication therapy (295 patients) or placebo (292 patients).
Objective: There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers for diagnosing adenoma.
Design: This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups.
Article Synopsis
- * P. anaerobius adheres to the CRC mucosa and activates signaling pathways in CRC cells via a surface protein called PCWBR2, which interacts with the α/β integrin receptor, leading to increased cell proliferation and an inflammatory response.
- * The study identifies the PCWBR2-integrin α/β signaling pathway as a potential therapeutic target to inhibit the oncogenic effects of P. anaerobius in CRC development.
Article Synopsis
- Patients with colorectal cancer (CRC) have a distinct gut microbiome, and this study aimed to identify viral taxonomic markers that could help in detecting CRC and predicting patient outcomes.
- Researchers analyzed fecal samples from CRC patients and controls across multiple cohorts, discovering that the variety of gut bacteriophages was notably higher in CRC patients.
- A set of 22 viral taxa effectively distinguished CRC cases from controls, with further validation showing significant associations with patient survival and alterations in microbial interactions.