Publications by authors named "Chun Chuan Lee"
Article Synopsis
- Cardiovascular diseases (CVD) are a major global health issue, and the study highlights the significance of inflammation and atherosclerosis in their development.
- In a study of 3,278 participants in Taiwan, both the neutrophil-to-lymphocyte ratio (NLR) and the neutrophil-to-HDL cholesterol ratio (NHR) were found helpful in identifying individuals at high risk for CVD, with NHR being particularly effective.
- The research suggests that while NHR is a strong tool for CVD risk assessment, NLR may serve as a better predictor of all-cause mortality, indicating the complex relationship between inflammation and lipid levels in CVD.
Article Synopsis
- - MASLD is a widespread chronic liver disease, affecting over 30% of people globally, and is primarily linked to metabolic issues like insulin resistance and type 2 diabetes.
- - There is a significant two-way relationship between MASLD and diabetes, influencing each other's progression and treatment outcomes.
- - Collaborative efforts from Taiwanese health organizations have led to new guidelines aimed at improving patient care for those with both diabetes and MASLD, focusing on surveillance and management strategies.
Article Synopsis
- The study investigates the link between serum 25-hydroxyvitamin D (25(OH)D) levels and stroke risk, observing that higher concentrations of this vitamin are associated with a lower likelihood of having a stroke.
- Conducted from 1990 to 2011 with 1,778 participants, the research utilized observational and Mendelian randomization methods to analyze the data and found a significant correlation between increased 25(OH)D levels and decreased stroke risk, with a particular emphasis on hypertension as a mediating factor.
- The findings suggest that maintaining adequate 25(OH)D levels may reduce stroke risk, and that managing blood pressure could be key in preventing strokes among those low in this vitamin.
Background: Excess parathyroid hormone (PTH) is associated with an increased risk of cardiovascular disease (CVD).
Purpose: We aimed to evaluate the correlation between primary hyperparathyroidism (PHPT) and CVD or cardiovascular (CV) death.
Data Sources: Comprehensive searches of PubMed, Embase and ClinicalTrials.
We present an in-depth analysis of dyslipidemia management strategies for patients with diabetes mellitus in Taiwan. It critically examines the disparity between established guideline recommendations and actual clinical practices, particularly in the context of evolving policies affecting statin prescriptions. The focus is on synthesizing the most recent findings concerning lipid management in patients with diabetes mellitus, with a special emphasis on establishing consensus regarding low-density lipoprotein cholesterol treatment targets.
View Article and Find Full Text PDFBackground: Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, is an epochal oral antidiabetic drug that improves cardiorenal outcomes. However, the effect of early dapagliflozin intervention on left ventricular (LV) remodeling in patients with type 2 diabetes free from cardiovascular disease remains unclear.
Methods And Results: The ELUCIDATE trial was a prospective, open-label, randomized, active-controlled study that enrolled 76 patients with asymptomatic type 2 diabetes with LV ejection fraction ≥50%, randomized to the dapagliflozin 10 mg/day add-on or standard-of-care group.
Background: The residual risks of atherosclerotic cardiovascular disease in statin-treated patients with diabetes remain unclear. This study was conducted to identify factors associated with these residual risks in patients with no prior vascular event.
Methods: Data on 683 statin-using patients with type 2 diabetes mellitus (T2DM) from the Taiwan Diabetes Registry were used in this study.
Background: The promotion of mobile health (mHealth) and eHealth technologies as tools for managing chronic diseases, particularly diabetes mellitus, is on the rise. Nevertheless, individuals with diabetes frequently face a literacy gap that hinders their ability to fully leverage the benefits offered by these resources. Enhancing technology literacy to facilitate the adoption of mobile eHealth services poses a significant challenge in numerous countries.
View Article and Find Full Text PDFBackground: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian patients.
Methods: We searched the database of a single center in Taiwan for cases with a pathological diagnosis of ACC in the past 25 years.
Article Synopsis
- The study aimed to investigate the link between thyroid cancer and various cardiovascular conditions, including coronary artery disease, atrial fibrillation, and cerebrovascular disease, along with mortality.
- Researchers analyzed data from 15 studies involving over 771,000 patients, finding that thyroid cancer significantly increased the risk of cerebrovascular disease (RR 1.15) and atrial fibrillation (RR 1.59), while coronary artery disease risk also rose (RR 1.12).
- The treatment with radioactive iodine did not show any significant effect on cardiovascular disease risks (RR 1.00), highlighting the need for personalized treatment plans that consider cardiovascular impacts for thyroid cancer patients.
Treatment with levothyroxine and radioiodine contribute alternative cardiovascular function in adults with thyroid cancer. The risks of long-term cardiovascular conditions among thyroid cancer patients is unknown. This study aimed to compare the incidence of coronary heart disease (CHD), ischemic stroke (IS), and atrial fibrillation (AF) among adults with thyroid cancer with that of the general population, especially when stratified by age (< 65 and ≥ 65 years old).
View Article and Find Full Text PDFAim: To explore the effect of active insulin titration versus usual titration on glycaemic control in patients with type 2 diabetes mellitus uncontrolled with oral antidiabetic drugs (OADs).
Methods: In a 24-week, prospective and randomized study, 172 patients with uncontrolled type 2 diabetes were randomly assigned to either active titration or usual titration. Efficacy and safety outcomes included changes in glycated haemoglobin (HbA1c) and fasting plasma glucose, percentage of individuals achieving HbA1c<53 mmol/mol, and hypoglycaemic events.
Article Synopsis
- Insulin therapy in diabetes patients can lead to increased body weight and muscle loss, and this study compared the effects of two medications, empagliflozin (an SGLT2 inhibitor) and linagliptin (a DPP4 inhibitor), on body composition.
- After 24 weeks, patients taking empagliflozin experienced an average weight loss of -1.80 kg and a reduction in muscle mass (-1.39 kg) and total body water (-1.07 kg) compared to those on linagliptin.
- Although empagliflozin slightly reduced body fat mass more than linagliptin, the difference was not statistically significant, indicating a need for further research on the long-term
Predicting readmission due to severe hyperglycemia after a hyperglycemic crisis episode.
Diabetes Res Clin Pract
October 2022
Aim: This study aimed to investigate the readmission pattern and risk factors for patients who experienced a hyperglycemic crisis.
Methods: Patients admitted to MacKay Memorial Hospital for diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS) between January 2016 and April 2019 were studied. The timing of the first readmission for hyperglycemia and other causes was recorded.
Article Synopsis
- This study investigates the relationship between different anti-diabetic medications and fracture risk in patients with type 2 diabetes.
- It analyzed data from 161 studies involving over 191,000 patients, finding that certain medications like DPP-4 inhibitors and SGLT-2 inhibitors are associated with a higher risk of fractures compared to GLP-1 receptor agonists (GLP1-RA).
- GLP1-RA and sulfonylureas (SU) provide better protection against fractures compared to thiazolidinediones (TZD) and showed comparable effects to insulin in terms of fracture risk.
Introduction: Parathyroid cancer is a rare disease with high recurrence rate. The prognostic factors for recurrent parathyroid cancer are yet to be ascertained. We aimed to establish the association between recurrent parathyroid cancer and previously reported prognostic factors.
View Article and Find Full Text PDFThe protective effect of different healthy lifestyle scores for the risk of cardiovascular disease (CVD) was reported, although the comparisons of performance were lacking. We compared the performance measures of CVDs from different healthy lifestyle scores among Taiwanese adults. We conducted a nationwide prospective cohort study of 6042 participants (median age 43 years, 50.
View Article and Find Full Text PDFArticle Synopsis
- SGLT2 inhibitors are medications that have been effective in reducing major vascular events in type 2 diabetes patients, as shown in several randomized controlled trials (RCTs).
- A meta-analysis of five RCTs with over 46,000 participants found that SGLT2 inhibitors did not significantly affect the overall risk of stroke or its subtypes.
- However, the analysis revealed that SGLT2 inhibitors are associated with a significant 50% reduction in the risk of hemorrhagic stroke compared to placebo.
Article Synopsis
- Chronic kidney disease (CKD) has a notable link to peripheral arterial disease (PAD), especially in patients with type 2 diabetes, but existing data on this relationship vary based on kidney function.
- Between October 2013 and February 2015, researchers evaluated 1,254 type 2 diabetes patients using ankle-brachial index (ABI) tests to analyze how kidney function (measured by eGFR) and albumin levels (ACR) correlate with PAD risk.
- Results showed that lower eGFR and higher ACR both increase the risk of PAD, with the highest odds ratio for PAD found in patients with severely reduced kidney function and high albumin levels, indicating that combining eGFR and ACR provides a
Rationale: Nausea and vomiting are common in the early period of pregnancy and rarely seen as an overture to pancreatitis.
Patient Concerns: Here, we describe a 31-year-old pregnant woman who presented with progressive nausea and vomiting followed by severe epigastric pain. Biochemical data and sonographic features confirmed the occurrence of acute pancreatitis.
Background: Understanding how people with diabetes seek online health information and use health applications is important to ensure these electronic tools are successfully supporting patient self-care. Furthermore, identifying the relationship between patient mobile eHealth literacy (mobile eHL) and diabetes outcomes can have far-reaching utility, for example, in the design of targeted interventions to address mobile eHL limitations. However, only limited studies have explored the impact of mobile eHL in a population with diabetes.
View Article and Find Full Text PDFPulmonary route is the main route of drug delivery for patients with asthma and chronic obstructive pulmonary diseases, offering several advantages over the oral route. Determining the amount of drug deposited onto various parts of the respiratory tract allows for a good correlation to clinical efficacy of inhalation drug devices. However, current in vitro cascade impactors measure only the aerodynamic particle size distribution, which does not truly represent the in vivo deposition pattern in human respiratory tract.
View Article and Find Full Text PDFAims/introduction: To investigate the clinical outcomes of patients with type 2 diabetes mellitus (T2DM) who initiated dapagliflozin in real-world practice in Taiwan.
Materials And Methods: In this multicenter retrospective study, adult patients with T2DM who initiated dapagliflozin after May 1 2016 either as add-on or switch therapy were included. Changes in clinical and laboratory parameters were evaluated at 3 and 6 months.
To determine the association between combined lifestyle factors, including healthy diet, moderate alcohol consumption, non-smoking, physical activity, and optimal weight, and cardiovascular disease (CVD) risk among younger and older adults. We conducted a literature search using PubMed, EMBASE, Cochrane Library, and EBSCO databases up to November 30, 2019 and performed dose-response analysis, subgroup analysis and meta-regression with odds ratios and 95% confidence intervals (CIs). Twenty cohort studies involving 1,090,261 participants with 46,288 cardiovascular events and mean follow-up duration of 12.
View Article and Find Full Text PDFArticle Synopsis
- Pulse wave velocity (PWV) is a non-invasive measure of arterial stiffness, with brachial-ankle PWV specifically assessing peripheral arterial stiffness in patients with type 2 diabetes (T2DM).
- A study involving 846 T2DM patients found that higher PWV levels correlated with more severe forms of diabetic retinopathy (DR), categorized as no DR (NDR), non-proliferative (NPDR), and proliferative diabetic retinopathy (PDR).
- The results showed that patients in the highest PWV tertile (>19.6 m/s) had a significantly increased risk of developing PDR, highlighting that greater arterial stiffness is linked to worse eye complications in diabetes.