Publications by authors named "Chun Chu"

Background: Early childhood caries (ECC) is a major oral health problem among preschool children that can significantly influence children's quality of life. Machine learning can accurately predict the treatment outcome but its use in ECC management is limited. The aim of this study is to explore the application of machine learning in predicting the treatment outcome of ECC.

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Dental diseases represent a significant global health concern, with traditional treatment methods often proving costly and lacking in long-term efficacy. Emerging research highlights nanoparticles as a promising, cost-effective therapeutic alternative, owing to their unique properties. This review aims to provide a comprehensive overview of the application of antimicrobial and antioxidant nanoparticles in the management of dental diseases.

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Objectives: This study aims to examine kindergarten teachers' satisfaction and their perceived impact of an oral health education (OHE) training program.

Methods: This study followed the steps outlined in the Program Evaluation Standards in Public Health recommended by the Centers for Disease Control and Prevention. All kindergarten teachers in Hong Kong were invited to attend the OHE training.

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The development of laser technology has revolutionized dentistry, offering complementary and alternative approaches to traditional techniques. Lasers have been successfully integrated into various dental procedures, enhancing treatment outcomes and patient care. Several types of lasers can increase the acid resistance of enamel, thus preventing caries.

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Dentist-patient communication is at the core of providing quality dental care. This study aims to review the importance, challenges, strategies, and training of dentist-patient communication. The World Dental Federation (FDI) emphasizes the importance of effective communication between oral healthcare providers and patients as a critical component of high-quality care.

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Cardiovascular disease (CVD) is currently a major factor affecting human physical and mental health. In recent years, the relationship between intracellular Ca and CVD has been extensively studied. Ca movement across the mitochondrial inner membrane plays a vital role as an intracellular messenger, regulating energy metabolism and calcium homeostasis.

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() is the main pathogenic bacterium causing dental caries, and the modes in which its traits, such as acid production, acid tolerance, and adhesion that contribute to the dental caries process, has been clarified. However, a growing number of animal experiments and clinical revelations signify that these traits of are not restricted to the detriment of dental tissues. These traits can assist in evading the immune system within body fluids; they empower to adhere not merely to the surface of teeth but also to other tissues such as vascular endothelium; they can additionally trigger inflammatory reactions and inflict damage on various organs, thereby leading to the occurrence of systemic diseases.

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: The World Health Organisation (WHO) included silver diamine fluoride (SDF) in the WHO Model List of Essential Medicines for the management of early childhood caries. SDF is typically available as a 38% aqueous solution, which is watery to apply. A 38% SDF gel has recently been developed, but its caries-arrest effectiveness remains unsubstantiated.

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Background: -acyl homoserine lactones (AHLs) are small signalling molecules predominantly secreted in Gram-negative bacteria.

Objective: The aim is to provide a comprehensive overview of AHLs in oral health.

Methods: Two independent researchers conducted a systematic search of English language publications up to 30 June 2024 in PubMed, Scopus and Web of Science.

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This study explored the knowledge, attitude, and practice towards silver diamine fluoride (SDF) therapy among dentists in Hong Kong. The quantitative component was an online closed-ended questionnaire survey through the Society of Preventive Dentistry of Hong Kong. The qualitative component involved individual in-depth interviews with selected dentists.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of GAPI peptide in combating bacteria and promoting remineralization in artificial enamel caries created by Streptococcus mutans.
  • GAPI treatment significantly reduced S. mutans viability and biofilm growth, resulting in less enamel damage and greater remineralization compared to the control group.
  • Findings indicated that GAPI not only decreased lesion depth and mineral loss but also improved the calcium-to-phosphorus ratio and hardness of enamel, suggesting strong antibacterial and remineralizing properties.
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Objective: The objectives of this study were to develop a tooth-binding graphene quantum dots silver nanocomposites (ALN-GQDs-Ag) and evaluate their antibacterial, mineralising, and discolouring properties for the prevention of dental caries.

Methods: In this study, ALN-GQDs-Ag were developed by synthesising nano silver (Ag) with graphene quantum dots (GQDs) and functionalised GQDs with alendronate (ALN). ALN-GQDs-Ag were characterised by transmission electron microscopy (TEM), zeta potential analysis, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy.

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Objective: To investigate the antibacterial, remineralising, and discolouring effects of copper tetraamine fluoride (CTF) on artificial enamel caries.

Method: Human enamel blocks with artificial caries were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before being challenged with Streptococcus mutans. The morphology, viability, and growth kinetics of biofilm were evaluated using scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting.

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Objective: To investigate the antibacterial, mineralising, and discolouring properties of copper tetraamine fluoride (CTF) on artificial dentine caries.

Method: Demineralised human dentine blocks were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before they were subjected to cariogenic challenge with Streptococcus mutans biofilm. The morphology, viability, and growth kinetics of the biofilm were assessed by scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting.

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Objective: To investigate the preventive effect of silver diamine fluoride (SDF) modified salivary pellicle (SP) against dental erosion.

Methods: Enamel and dentin blocks allocated into 4 groups (n = 30 each). Blocks in Group SDF+SP were treated with SDF and SP.

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Article Synopsis
  • * They have strong antibacterial effects, capable of inhibiting harmful bacteria, disrupting cell membranes, and preventing biofilm formation, thereby reducing the risk of cavities.
  • * Different synthesis methods allow researchers to control the size and shape of silver nanoparticles, enhancing their application in dental materials like composite resins to improve their longevity and reduce secondary caries.
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  • This study analyzes the role of polyamines in oral health, particularly among older adults, and their dysregulation linked to inflammatory and cancer conditions.
  • Researchers reviewed literature from 2000 to May 2024, identifying 19 relevant studies out of 2725 publications focused on older adults (65+).
  • Findings indicate increased polyamine levels, like spermidine and putrescine, in those with oral carcinoma, periodontal infections, and halitosis, suggesting these compounds could serve as non-invasive biomarkers for these conditions.
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  • The study systematically reviewed how secondary smoking affects early childhood caries (ECC) in preschool children, focusing on children under 71 months old.
  • Out of 1243 publications, only 16 met the criteria for inclusion, leading to a meta-analysis showing that children exposed to secondary smoking have a significantly higher risk of developing caries.
  • The findings suggest a clear correlation between secondary smoking and ECC, but emphasize that further high-quality research is needed to strengthen these conclusions.
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Article Synopsis
  • The study aimed to assess dental caries, erosive tooth wear, and oral health habits among 12-year-old children in Hong Kong through a cross-sectional survey.
  • A total of 445 children were recruited, with 396 participating, showing that 18% had caries experience, with a mean DMFT of 0.29.
  • Most children exhibited no signs of erosive tooth wear, but those consuming acidic drinks frequently had higher wear scores, while the majority maintained good oral hygiene practices like daily tooth brushing.
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Objectives: This systematic review aimed to evaluate the effectiveness of psychological interventions in improving oral health behaviors and status among adolescents.

Sources: A comprehensive search was conducted in the following six electronic databases, PubMed, Ovid Medline, Ovid Embase, Cochrane Library, APA PsycINFO (ProQuest) and Web of Science.

Study Selection: The PICO format was used to select eligible studies.

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Article Synopsis
  • The systematic review aimed to analyze methods for reducing discoloration from silver diamine fluoride (SDF) on carious lesions after application.
  • Two researchers reviewed literature up to April 2024, including 33 studies that met criteria for original research, focusing on methods to minimize SDF-induced discoloration while excluding irrelevant publications.
  • Key strategies identified included masking with restorations, using various chemicals (like oxidizing and chelating agents), and substituting regular silver with nano-silver to prevent discoloration.
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Background: Increasing studies have shown that poor oral health contributes to the progression of dementia. It is meaningful to find out the role of oral health interventions in maintaining people's cognition levels and delaying the progression of dementia. Thus, we conducted this review to summarize the present evidence on the effect of oral health interventions on the cognition change of people with dementia.

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Objective: To develop a novel and biocompatible copper tetraamine fluoride (CTF) with antibacterial and nondiscolouring properties.

Method: This study used copper fluoride and ammonia solution to develop CTF solution. The CTF was characterized by X-ray photoelectron spectroscopy (XPS).

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The objective of this prospective 12-month observational study is to examine the oral health-related quality of life (OHRQoL) among Hong Kong young children aged 3-4 years old receiving silver diamine fluoride (SDF) therapy for carious upper anterior primary teeth. A parental questionnaire was used to collect each child's sociodemographic background and oral health habits at baseline. Data on parents' satisfaction with their child's dental aesthetics were collected at baseline and during a 12-month visit.

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Objective: This systematic review aimed to describe and evaluate the caries patterns among the 21st century preschool children globally.

Method: Six electronic databases (Pubmed, Embase, Medline, Web of Science, EBSCOhost, and Scopus) were searched using predetermined terms. Dual independent screening of all retrieved abstracts was performed to identify studies conducted after year 2000 and the caries pattern among preschool children was investigated.

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