A Study of Mixed Non-Motorized Traffic Flow Characteristics and Capacity Based on Multi-Source Video Data.

Mixed non-motorized traffic is largely unaffected by motor vehicle congestion, offering high accessibility and convenience, and thus serving as a primary mode of "last-mile" transportation in urban areas. To advance stochastic capacity estimation methods and provide reliable assessments of non-motorized roadway capacity, this study proposes a stochastic capacity estimation model based on power spectral analysis. The model treats discrete traffic flow data as a time-series signal and employs a stochastic signal parameter model to fit stochastic traffic flow patterns.

Improved Unsupervised Stitching Algorithm for Multiple Environments SuperUDIS.

Large field-of-view images are increasingly used in various environments today, and image stitching technology can make up for the limited field of view caused by hardware design. However, previous methods are constrained in various environments. In this paper, we propose a method that combines the powerful feature extraction capabilities of the Superpoint algorithm and the exact feature matching capabilities of the Lightglue algorithm with the image fusion algorithm of Unsupervised Deep Image Stitching (UDIS).

Integration of high-resolution mass spectrometry technology with molecular network analysis and systems biology techniques to elucidate the active ingredients and mechanisms of Shiduqing capsules.

Rationale: Shiduqing Capsules, a well-known Chinese patent medicine, are widely used clinically for the treatment of pruritus. However, to date, there is a lack of research on its pharmacological substances and mechanisms of action.

Methods: In the current study, the chemical components of Shiduqing Capsules were identified using UHPLC-QE-Orbitrap-MS technology.

Identification of active ingredients in Naomaitai capsules using high-resolution mass spectrometry unite molecular network analysis and prediction of their action mechanisms.

Rationale: Although Naomaitai capsule (NMC) is widely used in clinical practice and has a good curative effect for cerebral infarction, its material basis and mechanism of action remain unclear.

Methods: In this study, ultra-high-performance liquid chromatography (UHPLC) coupled with quadrupole Orbitrap MS technology was used to analyse the in vivo and in vitro components of NMC, and the Global Natural Products Social Molecular Networking website was used to further analyse the components of NMC. Next, systems biology approaches were employed to investigate the mechanism of action of NMC.

AtSRT1 regulates flowering by regulating flowering integrators and energy signals in Arabidopsis.

Epigenetic modifications, such as histone alterations, play crucial roles in regulating the flowering process in Arabidopsis, a typical long-day model plant. Histone modifications are notably involved in the intricate regulation of FLC, a key inhibitor of flowering. Although sirtuin-like protein and NAD-dependent deacetylases play an important role in regulating energy metabolism, plant stress responses, and hormonal signal transduction, the mechanisms underlying their developmental transitions remain unclear.

Ultrahigh-performance liquid chromatography Q-Exactive-Orbitrap mass spectrometry and molecular network analysis alongside network pharmacology to elucidate the active constituents and mechanism of action of Huahong tablet in treating pelvic inflammatory disease.

Rationale: Huahong tablet, a commonly used clinical Chinese patent medicine, shows good efficacy in treating pelvic inflammation and other gynaecological infectious diseases. However, the specific composition of Huahong tablets, which are complex herbal formulations, remains unclear. Therefore, this study aims to identify the active compounds and targets of Huahong tablets and investigate their mechanism of action in pelvic inflammatory diseases.

A preliminary study for the clinical effect of one combinational physiotherapy and its potential influence on gut microbial composition in children with Tourette syndrome.

Introduction: Tourette syndrome (TS) is a chronic neuropsychiatric disorder with unknown causes and inadequate therapies. Inspired by the important roles of gut microbiota in some mental illnesses, the interactions between gut microbiota and TS via the gut-brain axis have gained more and more attention. This study aimed to characterize the gut microbial profiles in children with TS, and explore the clinical effects of one combinational physiotherapy and its potential influence on gut microbial composition.

Dual-YOLO Architecture from Infrared and Visible Images for Object Detection.

With the development of infrared detection technology and the improvement of military remote sensing needs, infrared object detection networks with low false alarms and high detection accuracy have been a research focus. However, due to the lack of texture information, the false detection rate of infrared object detection is high, resulting in reduced object detection accuracy. To solve these problems, we propose an infrared object detection network named Dual-YOLO, which integrates visible image features.

Comprehensive genomic analyses of Vigna unguiculata provide insights into population differentiation and the genetic basis of key agricultural traits.

Vigna unguiculata is an important legume crop worldwide. The subsp. sesquipedalis and unguiculata are the two major types grown; the former is mainly grown in Asia to produce fresh pods, while the latter is mainly grown in Africa to produce seeds.

S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity to enhance plant stress tolerance in Arabidopsis.

Arabidopsis histone deacetylase HDA19 is required for gene expression programs of a large spectrum of plant developmental and stress-responsive pathways. How this enzyme senses cellular environment to control its activity remains unclear. In this work, we show that HDA19 is post-translationally modified by S-nitrosylation at 4 Cysteine (Cys) residues.

Varifocal liquid lens driven by a conical dielectric elastomer actuator.

A varifocal lens is an important part of optical systems with applications in biomedicine, photography, smartphones, and virtual reality. In this paper, we propose and demonstrate a varifocal liquid lens driven by a conical dielectric elastomer actuator. When the conical dielectric elastomer is subjected to an actuation voltage, the conical dielectric elastomer works as an out-plane actuator and makes the surface curvature of the liquid droplet increase; then the focal length of the proposed varifocal liquid lens changes.

Ultralow loss hollow-core negative curvature fibers with nested elliptical antiresonance tubes.

Hollow-core negative curvature fibers can confine light within air core and have small nonlinearity and dispersion and high damage threshold, thereby attracting a great deal of interest in the field of hollow core fibers. However, reducing the loss of hollow-core negative curvature fibers is a serious problem. On this basis, three new types of fibers with different nested tube structures are proposed in the near-infrared spectral regions and compared in detail with a previously proposed hollow-core negative curvature fiber.

A Novel Transformer-Based Attention Network for Image Dehazing.

Image dehazing is challenging due to the problem of ill-posed parameter estimation. Numerous prior-based and learning-based methods have achieved great success. However, most learning-based methods use the changes and connections between scale and depth in convolutional neural networks for feature extraction.

The Effect of Oral Nutritional Formula With Three Different Proteins on Type 2 Diabetes Mellitus .

Oral nutritional (ON) products are an effective way to treat patients with type 2 diabetes mellitus (T2DM) whose gastrointestinal functions are normal. The influence of ON formula prepared with three different proteins on T2DM was studied. The hyperglycaemic mouse model using a high-fat diet (HFD) combined with an intraperitoneal injection of streptozotocin (STZ) was used to simulate T2DM.

Tunable lens using dielectric elastomer sandwiched by transparent conductive liquid.

We propose and demonstrate a compact tunable lens with high transmittance using a dielectric elastomer sandwiched by transparent conductive liquid. The transparent conductive liquid not only serves as the refractive material of the tunable lens but also works as the compliant electrode of the dielectric elastomer. The overall dimensions of the proposed tunable lens are 16 mm in diameter and 10 mm in height, and the optical transmittance is as high as 92.

SDG711 Is Involved in Rice Seed Development through Regulation of Starch Metabolism Gene Expression in Coordination with Other Histone Modifications.

SDG711 is a histone H3K27me2/3 transmethylase in rice, a homolog of CLF in Arabidopsis, and plays key roles in regulating flowering time and panicle development. In this work, we investigated the role of SDG711 in rice seed development. Overexpression and downregulation of SDG711 lead to a decrease and increase in the expression level of genes related to starch accumulation, resulting in smaller seeds or even seed abortion.

Macrophage activation syndrome associated with adult-onset Still's disease: a multicenter retrospective analysis.

Objectives: To explore the clinical features, treatments, and prognostic factors of adult-onset Still's disease (AOSD)-associated macrophage activation syndrome (MAS), we conducted a multicenter retrospective clinical study of AOSD-associated MAS patients.

Methods: AOSD patients were collected from six tertiary hospitals in China. Medical charts were reviewed and clinical information was recorded and analyzed.

Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response.

Epigenetic regulation of gene expression is important for plant adaptation to environmental changes. Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis. However, how HDA9 targets to specific chromatin loci and controls gene expression networks involved in plant response to stress remains largely unclear.

Behaviors of Glioblastoma Cells in in Vitro Microenvironments.

Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers.

Alterations in microRNA expression profiles in inflamed and noninflamed ascending colon mucosae of patients with active Crohn's disease.

Background And Aim: The microRNA (miRNA) expression profiles of the terminal ileum, sigmoid colon, and rectal mucosa of adult patients with active Crohn's disease (CD) have been previously reported. The purpose of this study was to identify dysregulated miRNAs in the mucosa of the ascending colon.

Methods: Biopsy tissue samples were taken from the mucosae of inflammatory (iCD) or noninflammatory (niCD) areas of the ascending colons of adult patients with active CD.

Alterations in brain grey matter structures in patients with crohn's disease and their correlation with psychological distress.

Background: Whether Crohn's disease [CD] is correlated with brain structural changes is unclear. This study examined changes in grey matter [GM] structures in CD patients and their correlation with psychological distress.

Methods: A total of 45 CD patients and 33 healthy controls were scanned using magnetic resonance imaging [MRI].

Exon-intron circular RNAs regulate transcription in the nucleus.

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells.

Structural and permeation kinetic correlations in PdCuAg membranes.

Addition of Ag is a promising way to enhance the H2 permeability of sulfur-tolerant PdCu membranes for cleanup of coal-derived hydrogen. We investigated a series of PdCuAg membranes with at least 70 atom % Pd to elucidate the interdependence between alloy structure and H2 permeability. Membranes were prepared via sequential electroless plating of Pd, Ag, and Cu onto ceramic microfiltration membranes and subsequent alloying at elevated temperatures.