Synergetic antibacterial nanosheet based on TiCT photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms.

Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using TiCT MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu) simple electrostatically co-assemble.

Self-Assembled Borneol-Guanidine-Based Amphiphilic Polymers as an Efficient Antibiofilm Agent.

Biofilm-associated infections remain a tremendous obstacle to the treatment of microbial infections globally. However, the poor penetrability to a dense extracellular polymeric substance matrix of traditional antibacterial agents limits their antibiofilm activity. Here, we show that nanoaggregates formed by self-assembly of amphiphilic borneol-guanidine-based cationic polymers (BGN-) possess strong antibacterial activity and can eliminate mature () biofilms.

Long-Lasting Antibacterial PDMS Surfaces Constructed from Photocuring of End-Functionalized Polymers.

A challenge remains in the development of anti-infectious coatings for the inert surfaces of biomedical devices that are prone to bacterial colonization and biofilm formation. Here, a facile photocuring method to construct functionalized polymeric coatings on inert polydimethylsiloxane (PDMS) surfaces, is developed. Using atom transfer radical polymerization (ATRP) initiator bearing thymol group, hydrophilic DMAEMA and benzophenone (BP)-containing monomers are copolymerized to form polymers with end functional groups.

Bacteria-targeted photothermal therapy for combating drug-resistant bacterial infections.

Photothermal therapy is an ideal non-invasive treatment for bacterial infections. However, if photothermal agents are unable to target bacteria, they can also cause thermal damage to healthy tissue. This study describes the fabrication of a TiCT MXene-based photothermal nanobactericide (denoted as MPP) that targets bacteria by modifying MXene nanosheets with polydopamine and the bacterial recognition peptide CAEKA.

Citronellol-Based Long-Lasting Antibacterial Cotton Fabrics without Bacterial Resistance.

Antibacterial cotton helps prevent the growth and spread of harmful microorganisms, reduces the risk of infection, and has a prolonged service life by reducing bacterial degradation. However, most antibacterial agents used are toxic to humans and the environment. Citronellol-poly(N,N-dimethyl ethyl methacrylate) (CD), a highly effective antibacterial polymer, is synthesized from natural herbal essential oils (EOs).

Evaluation on the Risk of Water Inrush Due to Roof Bed Separation Based on Improved Set Pair Analysis-Variable Fuzzy Sets.

To study and prevent bed separation water inrush accidents in coal mines, it is necessary to evaluate the risk according to the limited geological data correctly. In this work, based on hydrogeological and mining conditions, we established a risk evaluation model and selected seven important factors, including the aquifer thickness, aquifer water abundance, hydraulic pressure of the aquifer, effective aquifuge thickness, mining failure ratio, mining height of the working face, and advancing distance as evaluation indexes. The intuitionistic fuzzy analytic hierarchy process (IFAHP) and entropy weight method (EWM) were used to analyze the weights of the original data, and the minimum information entropy principle was used to further integrate the abovementioned calculation results.

-alkylation briefly constructs tunable multifunctional sensor materials: Multianalyte detection and reversible adsorption.

A series of -alkyl-substituted polybenzimidazoles (), synthesized by simple condensation and -alkylation, act as functional materials with tunable microstructures and sensing performance. For their controllable morphologies, the formation of nano-/microspheres is observed at the (RBr)/(PBI) feed ratio of 5:1. Products with different degrees of alkylation can recognize metal ions and nitroaromatic compounds (NACs).

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection.

A new type of conjugated polybenzimidazole () was synthesized through a simple polycondensation reaction without metal catalysis, and -alkylation modification was carried out to solve the problems of solubility and fluorescence properties. A series of nano-microsphere polymers with large conjugation, good solubility, and strong fluorescence has been successfully used as "turn-off" fluorescent probes for the first time. The results show that, under suitable -alkylation conditions, the obtained can be used as a highly sensitive and selective fluorescent probe for the detection of Cu and Zn at the same time, and their detection limits are both nM levels.

Quick construction of a C-N bond from arylsulfonyl hydrazides and C-X compounds promoted by DMAP at room temperature.

An efficient approach for C-N bond construction by the coupling reaction of arylsulfonyl hydrazides and C-X compounds is described for the first time with good yields at room temperature. The reaction promoted by the simple base DMAP displays excellent regioselectivity as well as high functional group tolerance with 41 examples. Even for inactive C-Cl compounds, the metal-free transformation also affords a satisfactory yield after prolonging the reaction time, which is comparable to that of the corresponding C-Br compound.

Disproportionate Coupling Reaction of Sodium Sulfinates Mediated by BF·OEt: An Approach to Symmetrical/Unsymmetrical Thiosulfonates.

The BF·OEt-mediated disproportionate coupling reaction of sodium sulfinates was found for the first time. In this reaction, various S-S(O) bonds can be formed, efficiently giving thiosulfonates in moderate to excellent yields. As a convenient protocol for the synthesis of symmetrical and unsymmetrical thiosulfonates, its reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via a sulfinyl radical disproportionation.