Publications by authors named "Chul-Hwan Bang"
Cannabichromene (CBC) is one of the main cannabinoids found in the cannabis plant, and although less well known than tetrahydrocannabinol (THC) and cannabidiol (CBD), it is gaining attention for its potential therapeutic benefits. To date, CBC's known mechanisms of action include anti-inflammatory, analgesic, antidepressant, antimicrobial, neuroprotective, and anti-acne effects through TRP channel activation and the inhibition of inflammatory pathways, suggesting that it may have therapeutic potential in the treatment of inflammatory skin diseases, such as atopic dermatitis (AD), but its exact mechanism of action remains unclear. Therefore, in this study, we investigated the effects of CBC on Th2 cytokines along with the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in AD pathogenesis.
View Article and Find Full Text PDFSystemic sclerosis (SS) is an autoimmune disease and pathological mechanisms of SS are unclear. In this study, we investigated the role of T cells in the progression of SS using SKG mice and humanized mice. SKG mice have a spontaneous point mutation in ZAP70.
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- Generalized pustular psoriasis (GPP) is a rare and serious skin condition characterized by pustules and systemic symptoms, with differences in genetic mutations affecting its presentation and treatment among various ethnic groups.
- A modified Delphi panel study involving dermatology experts from the Asia-Pacific region aimed to establish a consensus on GPP management due to limited existing evidence and information.
- The panel reached agreement on 106 key statements addressing GPP’s definition, diagnosis, treatment strategies, and flare severity, creating treatment algorithms to assist clinicians in making informed decisions.
Article Synopsis
- Cannabidiol (CBD) has been studied for its potential to treat psoriasis, a chronic skin disease affecting up to 3% of the global population, although its mechanisms of action are not fully understood.
- In a mouse study, researchers assessed the effects of varying concentrations of CBD and clobetasol on psoriasis induced by imiquimod, measuring severity through the Psoriasis Area and Severity Index (PASI) and examining tissue changes.
- Results indicated that CBD significantly reduced psoriasis symptoms and inflammation, suggesting it works by inhibiting the IL-23 receptor-mediated JAK2-STAT3 signaling pathway, positioning it as a potential therapeutic option for psoriasis.
Article Synopsis
- Bimekizumab treatment has shown significant improvements in patients with moderate to severe plaque psoriasis, but previous studies mostly included White populations from North America and Europe, with limited data on Asian populations like Koreans.* -
- In a study of 47 Korean patients, those treated with bimekizumab experienced much higher rates of clinical improvement by week 16 compared to placebo, achieving PASI 90 (81.3% vs. 0%) and IGA scores of 0/1 (87.5% vs. 0%).* -
- The treatment also resulted in rapid improvements in health-related quality of life, with 46.9% of bimekizumab patients achieving a Dermatology Life
Article Synopsis
- * Findings revealed a significant increase in PsA prevalence, rising from 6.17 per 1,000 patients in 2008 to 19.03 in 2020, along with an increased incidence rate from 3.35 to 5.01 per 1,000 patient-years.
- * Key risk factors for developing PsA include having plaque PsO, moderate-to-severe psoriasis, receiving specific treatments (oral systemic therapy or phototherapy), and having other comorbid autoimmune diseases. *
Small plaque psoriasis is the typical form of chronic plaque psoriasis affecting adults in South Korea. The effectiveness of calcipotriol/betamethasone dipropionate (Cal/BD) aerosol foam for large and small psoriasis plaques has not previously been examined. We performed a post hoc analysis of a recent, 4-week observational study of Cal/BD aerosol foam use in routine clinical practice in South Korea.
View Article and Find Full Text PDFBackground: Secukinumab, a fully human monoclonal antibody, was approved in Korea for the treatment of moderate to severe psoriasis in September 2015.
Objectives: To assess the safety and effectiveness of secukinumab in patients with moderate to severe psoriasis in Korea.
Design: Multicenter, real-world, noninterventional study conducted over 6 years.
Knowledge and the behavioral patterns of photoprotection among Koreans with skin disease.
Photodermatol Photoimmunol Photomed
January 2024
Article Synopsis
- Photoprotection is vital for preventing skin disease progression, yet awareness among patients with skin conditions is low; a study assessed this knowledge and behavior in South Korea.
- The study involved 1,173 patients, revealing that females and younger individuals had significantly better knowledge of photoprotection than their counterparts, but many still displayed inadequate protective behaviors.
- Results highlighted that males and patients with skin cancer exhibited the lowest knowledge and engagement in protective measures, suggesting a need for targeted educational initiatives.*
Introduction: Previously, we achieved large-scale expansion of bone marrow-derived suppressor cells (MDSCs) derived from cluster of differentiation (CD)34 cells cultured in human umbilical cord blood (hUCB) and demonstrated their immunomodulatory properties. In the present study, we assessed the therapeutic efficacy of hUCB-MDSCs in atopic dermatitis (AD).
Methods: (Df)-induced NC/Nga mice (clinical score of 7) were treated with hUCB-MDSCs or a control drug.
Importance: Vitiligo is a multifactorial, depigmenting skin disorder characterized by selective loss of melanocytes. Large-scale studies are lacking to determine the risk of vitiligo in transplant recipients with graft-vs-host disease (GVHD).
Objective: To investigate the incidence rates and risk of vitiligo in patients who had received solid organ transplant (SOT) or hematopoietic stem cell transplant (HSCT) overall and by HSCT graft type and concomitant GVHD.
Pigmented contact dermatitis and hair dyes: A retrospective case-control multicentre study in Korea.
J Eur Acad Dermatol Venereol
December 2023
Background: Pigmented contact dermatitis (PCD), a rare variant of non-eczematous contact dermatitis, is clinically characterized by sudden-onset brown or grey pigmentation on the face and neck. It is hypothesized to be caused by repeated contact with low levels of allergens.
Objectives: This study evaluated the risk of using hair dyes in patients with PCD in Korea.
Acantholytic dyskeratotic acanthoma: A rare and underappreciated entity.
Indian J Dermatol Venereol Leprol
November 2023
Article Synopsis
- Normal skin contains many clones with cancer driver mutations, but its relationship to skin cancer is still not fully understood.
- The study used whole-exome sequencing on normal skin tissues and compared them to matched blood and skin cancers, finding that exposed skin had significantly more mutations than nonexposed skin.
- Key driver mutations were identified in genes linked to skin cancer, and although normal skin had some genetic changes, there was little connection to mutations found in adjacent skin cancers.
Article Synopsis
- Three-dimensional melanoma culture serves as a personalized model for testing new therapies, but its similarity to original primary tumors was previously uncertain.
- The study involved establishing patient-derived xenograft tumors and creating 3D cultures to compare their genomic landscapes using whole-exome sequencing.
- Results showed a high concordance of genetic profiles between the original tumors and the 3D culture models, confirming the reliability of 3D cultures in representing the original tumors.
A previous study from our laboratory demonstrated the effects of three-dimensional (3D)-printed collagen scaffolds on the maintenance of cryopreserved patient-derived melanoma explants (PDMEs). However, it remains unknown whether 3D-printed collagen scaffolds (3D-PCSs) can be harmonized with any external culture conditions to increase the growth of cryopreserved PDMEs. In this study, 3D-PCSs were manufactured with a 3DX bioprinter.
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- This study examines the genomic alterations in Bowen's disease (BD) by analyzing whole-exome sequencing from multiple lesions in three patients.
- Researchers found a high median of 64 somatic mutations per sample, predominantly influenced by UV exposure, which accounted for about 65% of the mutations.
- The analysis indicates that each BD lesion is genetically unique, with no shared mutations across lesions, implying varying risks of malignant progression.