Publications by authors named "Chukwuwike Johnny"
Peripheral nerve injuries (PNIs) pose significant clinical challenges due to their complex healing processes and the often incomplete functional recovery. This review and bibliometric analysis aimed to provide a comprehensive overview of advancements in peripheral nerve regeneration research, focusing on trends, influential studies, and emerging areas. By analyzing 2921 publications from the Web of Science Core Collection, key themes such as nerve regeneration, repair, and the critical role of Schwann cells were identified.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma (GB) is a highly aggressive brain tumor in adults with complex genetics, making it difficult to treat effectively; current therapies are limited and often ineffective.
- This systematic review, adhering to PRISMA guidelines, analyzed studies from several databases to explore emerging treatments focused on glioblastoma stem cells and advanced drug delivery systems, culminating in 24 eligible peer-reviewed articles from an initial 755 found.
- While the review highlights promising new therapies, it points out limitations like potential language bias, variability among studies, and reliance on preclinical models, emphasizing the need for continuous research in this complex area.
Cancer therapy advancements have improved survival rates but also introduced significant cardiotoxic risks. Cardiotoxicity, a critical adverse effect of cancer treatments such as doxorubicin, trastuzumab, and radiotherapy, poses substantial challenges. This systematic review synthesizes findings from studies on cardiotoxicity induced by cancer therapies, focusing on detection and management.
View Article and Find Full Text PDFDilated cardiomyopathy (DCM) is a prevalent heart muscle disease characterized by ventricular dilation and systolic dysfunction, leading to severe heart failure (HF) and often requiring heart transplantation (HTx). This systematic review aimed to synthesize information regarding the role of ventricular assist devices (VADs) in managing HF patients due to DCM. A comprehensive search was conducted across PubMed, Embase, Scopus, Web of Science, and Cochrane databases for studies published between 2014 and 2024.
View Article and Find Full Text PDF