Publications by authors named "Chukwuka Uzoamaka Ogbonna"
Long-term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA) has pertinent neuropharmacological characteristics, its effect against DEP + BPS-induced neurotoxicity has not been explored. This study proposed that VA may offer protection against the neurotoxicity caused by DEP + BPS.
View Article and Find Full Text PDFMorin attenuates neurobehavioural deficits, hippocampal oxidative stress, inflammation, and apoptosis in rats co-exposed to bisphenol S and diethyl phthalate.
Brain Res
November 2022
Article Synopsis
- Endocrine-disrupting pollutants (EDPs) like Bisphenol S (BPS) and diethyl phthalates (DEP) are common environmental toxins that may cause neurotoxicity, which was examined in male Wistar rats.
- Exposure to a mixture of BPS and DEP resulted in anxiety-like behaviors, cognitive and motor impairments, and increased oxidative stress markers.
- Treatment with morin showed protective effects by improving neurobehavioral outcomes, reducing enzyme hyperactivity, and decreasing oxidative stress and inflammation in the rats.
Morin Augmented Myocardial eNOS/cGMP/PKG Signaling Pathway and Abated Oxidative and Inflammo-apoptotic Responses in Diethyl Phthalate and Bisphenol-S Co-Exposed Male Albino Rats.
Inflammation
February 2023
Cardiac failure accounts for many deaths worldwide. Increasing experimental evidence suggests that exposure to chemicals such as bisphenol-S (BPS) and diethyl phthalate (DEP) exacerbate cardiac injuries. Morin is a flavonoid with reported cardioprotective activity.
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