Publications by authors named "Chuka Jenkins"

Objective: To derive a prediction rule for preeclampsia and early onset preeclampsia requiring delivery <34 weeks using first trimester maternal, ultrasound, and serum markers.

Study Design: Prospective cohort study of women enrolled at first trimester screening. Maternal history, demographics, anthropometry, ultrasound parameters, and serum analytes were compared between women with preeclampsia and normal outcome.

View Article and Find Full Text PDF

Objective: First-trimester screening for subsequent delivery of a small-for-gestational-age (SGA) infant typically focuses on maternal risk factors and uterine artery (UtA) Doppler. Our aim is to test if incorporation of fetal umbilical artery (UA) and ductus venosus (DV) Doppler improves SGA prediction.

Study Design: Prospective screening study of singletons at 11-14 weeks.

View Article and Find Full Text PDF

Objective: The residual risk of preeclampsia in high-risk women on aspirin prophylaxis exceeds that of low-risk populations, and this study aimed to identify first-trimester maternal characteristics associated with aspirin prophylaxis failure.

Methods: This is a nested cohort study of prospectively enrolled women with verified initiation of risk-indicated aspirin prophylaxis by 16 weeks of gestation. First-trimester maternal history, demographics, anthropometry, ultrasound parameters, and serum analytes were compared between women who developed preeclampsia and those who did not.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined how previous preeclampsia affects early pregnancy assessments in women during subsequent pregnancies.
  • The research involved 1,283 women in their first trimester, comparing ultrasound results and placental factors between those with and without a history of preeclampsia, finding no significant differences.
  • It concluded that while prior preeclampsia doesn't impact early ultrasound or placentas directly, its effects can worsen with more pregnancies and are largely related to blood pressure, suggesting the importance of lifestyle changes and better blood pressure management for these patients.
View Article and Find Full Text PDF

Objective: Pentraxin (PTX)-3 is an inflammatory molecule that may be increased in the first trimester in pregnancies with subsequent preeclampsia. We measured first-trimester serum PTX-3 and correlated levels with maternal/placental factors related to placental development.

Study Design: Prospectively enrolled women had ultrasound, physical examination, and blood draw at 11-14 weeks.

View Article and Find Full Text PDF

Angiopoietin-2 (Ang-2), synthesized by endothelial cells, is a marker of placental vascular remodeling. Ang-2 is expressed in the first trimester, and levels may therefore correlate to other parameters of placental vascular development. The aim of this study was to evaluate the relationships between Ang-2 and other maternal/placental factors in the first trimester.

View Article and Find Full Text PDF