Upper Airway Changes After Mandibular Setback and/or Advancement Genioplasty in Obese Patients.

Purpose: Orthognathic surgeries, such as bilateral sagittal split ramus osteotomy (BSSO) and genioplasty, can influence the pharyngeal airway space (PAS) and this has been supported by previous studies. The purpose of this study was to assess changes of the PAS in patients with a high body mass index (BMI) likely to have narrow airways before and after setback BSSO with or without advancement genioplasty surgery by 3-dimensional computed tomography.

Materials And Methods: Thirty-five adults with a BMI of at least 24.

[Study of human leucine-rich amelogenin peptide and its regulation of mineralization by cryogenic transmission electron microscopy].

Objective: Recombinant human leucine-rich amelogenin peptide (LRAP) was studied by cryogenic transmission electron microscopy (TEM); evaluation focused on its self-assembly and crystal growth in vitro.

Methods: Human LRAP was recombined through prokaryotic expression vector pCold-SUMO and transformed into Escherichia coli BL21plys to acquire purified proteins. Cryogen TEM recorded assembly and self-assembling of LRAP from pH 3.

Surgical correction without bone grafts of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint ankylosis.

Objective: With the inclusion criteria of patients confirmed and the therapeutic effects and stability evaluated, this article presents the clinical value of bimaxillary orthognathic surgery without bone graft of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint (TMJ) ankylosis.

Study Design: From 2008 to 2012, 12 patients with dentomaxillofacial asymmetric deformities secondary to unilateral TMJ ankylosis who had undergone TMJ reconstruction as the primary surgery were included in the study. Preoperatively, all patients had compensatory occlusal plane and maxillary inclination <10° and mandibular advancement <15 mm according to computer-assisted 3-dimensional surgical simulation and prediction.

Application of Intraoperative Navigation for the Reconstruction of Mandibular Defects With Microvascular Fibular Flaps-Preliminary Clinical Experiences.

Background: A microvascular fibular flap is the main option for the reconstruction of mandibular defects. This paper introduces an innovative strategy for the accurate fabrication of fibular flaps.

Methods: Nine patients with mandibular tumors were included in this study.

Bimaxillary Orthognathic Approach to Correct Skeletal Facial Asymmetry of Hemifacial Microsomia in Adults.

Background: Hemifacial microsomia (HFM) is the second most common congenital craniofacial deformity after cleft lip and palate. Distraction osteogenesis (DO) is regarded as an alternative and efficient treatment option for patients with HFM. However, DO was not proven effective for all cases, and the results of long-term follow-up were not satisfactory as expected.

[Chitosan-collagen polymer induced remineralization of tooth hard tissue through self-growing methods].

Objective: To modify biomacromolecules, such as chitosan and collagen, to synthesize a mineralized template that will induce self-growing remineralization of tooth enamel.

Methods: Natural polycation polysaccharide chitosan was modified through phosphorylation to synthesize the polyanion derivative ofphosphorylated chitosan. Parent hydrogels com- bined with chitosan and collagen I were built through peptide binding reaction using genipin as a crosslinker.

Expression and distribution of TNF-α and PGE2 of periodontal tissues in rat periodontitis model.

Objective: To simulate the expression of TNF-α and PGE2 of periodontal tissues in rat periodontitis model.

Methods: 40 Wistar rats were randomly divided into the periodontitis group and the control group (n=20). After the successful establishment of periodontitis rat model, raising for six weeks before the animals were sacrificed.

Hyperthermia inhibited the migration of tongue squamous cell carcinoma through TWIST2.

Background: Hyperthermia has been shown promising in the treatment of head and neck squamous cell carcinoma (HNSCC); however, the mechanism underlying hyperthermia reducing tumor metastasis is poorly elucidated. TWIST2, an important transcription factor of epithelial-mesenchymal transition (EMT), plays a critical role in the tumor progression and metastasis. The role of TWIST2 in tongue squamous cell carcinoma (TSCC) and its association with hyperthermia still have not been reported.

Regeneration of tooth-like hydroxyapatite depended on amelogenin functional section monolayer: a new approach for tooth repair.

Tooth defect due to caries, trauma, or acid corrosion are common in mankind. Ceramics, metal and resin were used to repaired tooth defect in the past hundred years, but they cannot instead enamel and dentin in depth in clinic usage for the difference in structure and element. So the formation of organized nanocrystals that resemble enamel is crucial for successful enamel remineralization.

[Experimental study of the bioresorbable collagen membrane used for guided bone regeneration around dental implants].

Objective: To investigate the effects of using guided bone regeneration (GBR) technique with an bioresorbable collagen membrane for repairing bone defects around dental implants.

Methods: In 12 mongrel dogs, pure titanium implants were immediately implanted in mandibles after extraction of the mandibular third and fourth premolars of both sides, in which standard bone defects of 3 mm x 3 mm x 5 mm were created at mesial side of the implants. The defects on right side were covered with Co membrane, the left side was uncovered as control.

[The clinical application and evaluation of combined chemotherapy in comprehensive treatment for oral squamous cell carcinoma].

Objective: To study and evaluate the clinical effects of combined preoperative chemotherapy and their relations with multi drug resistance (MDR).

Methods: 102 cases with oral squamous cell carcinoma(OSCC) were included in the study (63 males and 39 females, aged 22 to 67 years). Among the subjects there were 57 cases with cancer of tongue and 45 cases with cancer of buccal mucosa.

[Clinical characters, diagnosis and treatment of parapharyngeal region neoplasms: a report of 115 cases].

Objective: The aim of this study was to analyze the clinical characters, diagnosis and treatment of primary neoplasms in the parapharyngeal regions.

Methods: A total of 115 cases of primary neoplasms in the parapharyngeal regions were included in this study.

Results: Disorders of swallowing, breath or speaking were the common symptoms of neoplasms in parapharyngeal regions.