Publications by authors named "Chufan Lu"
Article Synopsis
- Brain metastases (BM), including brain parenchyma metastases (BPM) and leptomeningeal metastases (LM), are severe complications in advanced cancer, particularly non-small cell lung cancer (NSCLC), and next-generation sequencing (NGS) may help diagnose these conditions by profiling genetic mutations.
- A study analyzed cerebrospinal fluid (CSF) and plasma samples from 37 NSCLC-BM patients, finding that detectable circulating tumor DNA (ctDNA) in the CSF was significantly elevated compared to plasma, with the mutations found being consistent with primary tumors and additionally showing unique characteristics.
- The results suggest that analyzing CSF ctDNA through NGS can provide insights into the molecular features of
Background: Non-small cell lung cancer with leptomeningeal metastasis (NSCLC-LM) is emerging as a new management challenge for oncologists and is associated with poor prognosis. This study aimed to investigate the molecular characteristics and prognostic factors of NSCLC-LM.
Methods: This retrospective study included 97 patients with NSCLC-LM between January 2015 and October 2021.