Publications by authors named "Chuck W Locuson"
Article Synopsis
- - A new positive allosteric modulator (PAM), (S)-9b, was discovered through a high throughput screening process aimed at enhancing glucagon-like peptide-1 receptor (GLP-1R) activity.
- - (S)-9b increased the effectiveness of low-dose exenatide, leading to improved insulin secretion in mouse pancreatic islets.
- - The compound also showed potential in reversing catalepsy caused by haloperidol by boosting the activity of endogenous GLP-1R.
CYP2C9 substrates can exhibit both hyperbolic and atypical kinetic profiles, and their metabolism can be activated or inhibited depending on the effector studied. CYP2C9 genetic variants can also affect both substrate turnover and kinetic profile. The present study assessed whether analogs of the effector amiodarone differentially altered the atypical kinetic profile of the substrate naproxen and whether this effect was genotype-dependent.
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