Publications by authors named "Chuck Foley"
Article Synopsis
- Chicken blastodermal cells can be cultured briefly and still contribute to various tissues in gamma-irradiated embryos, but creating transgenic birds has been challenging due to low integration rates of transgenes into their genomes.*
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- This study developed two methods to successfully isolate and culture blastodermal cells with integrated transgenes from specific chicken embryos, using chick embryo extract to promote cell growth.*
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- Although injected into irradiated embryos resulted in chicks with donor cell tissues and detectable transgene sequences in sperm DNA, breeding these chimeric birds did not lead to successful germline transmission of the transgene.*
