Publications by authors named "Chuchu Ye"

Article Synopsis
  • Infectious diseases are a major global health issue, creating a need for accurate predictive models, which the Baidu index can enhance through real-time data.
  • Data on the keyword "fever" was collected from 255 Chinese cities to identify when influenza epidemics began and peaked, using specific statistical thresholds.
  • An optimal method for detecting epidemic starts involves monitoring when a threshold is surpassed for several days, while peak detection is best achieved through a moving average for stability and accuracy, showcasing improved disease surveillance potential.
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What Is Already Known About This Topic?: Noroviruses are highly infectious with rapid transmission capabilities, causing illness for an average duration of 12-60 hours. In China, individuals in educational agencies may return to class 72 hours after symptom resolution.

What Is Added By This Report?: This outbreak was precipitated by a potential source of infection in a child resuming class after a 72-hour quarantine post-symptom resolution, leading to a cluster of cases within the class.

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  • This study examined the inactivated A71 (EV-A71) vaccination levels and its impact on hand-foot-mouth disease (HFMD) in Pudong New Area, Shanghai, using data from 2016 to 2022.
  • Out of 484,056 vaccine doses given, the first dose vaccination rate was 14.03%, while the full vaccination rate was 13.33%, and significant yearly differences were found.
  • Despite the low vaccine coverage, HFMD incidence showed a decline post-vaccination, with most cases being caused by non-EV-A71 and non-CV-A16, highlighting the need for new combined vaccines for better protection.
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  • The study investigates the prevalence and molecular characteristics of hypermucoviscous and hypervirulent Klebsiella pneumoniae (hm-hvKp) isolates in community patients from Shanghai, China, addressing a significant public health concern due to limited data on these isolates in community settings.* -
  • Conducted in 2018, the research included an active surveillance system at 12 hospitals, analyzing fecal samples for antimicrobial susceptibility and using whole-genome sequencing to identify key genetic features, such as virulence and resistance patterns.* -
  • Findings revealed a 2.48% prevalence of hm-hvKp isolates, with distinct types ST23/KL1 and ST86/KL2 being predominant; these
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Article Synopsis
  • A study conducted in Shanghai from 2013 to 2022 examined viral causes of acute respiratory infections (ARIs) in children aged 0-14 years, revealing a large burden of disease.
  • Results showed that 30.67% of children tested positive for at least one respiratory virus, with influenza virus (IFV) being the most prevalent followed by respiratory syncytial virus (RSV) and para-influenza virus (PIV).
  • The findings highlighted the need for targeted interventions, including diagnosis, treatment, and vaccination, as different age groups showed varying risk levels for specific viruses.
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Objectives: The concurrent impact of COVID-19 and influenza on disease burden is a topic of great concern. This discussion delves into the epidemiological characteristics of seasonal influenza activity in Shanghai within the context of the SARS-CoV-2 epidemic.

Methods: From 2017 to 2023, a total of 11,081 patients having influenza-like illness (ILI) were included in this study for influenza virus detection.

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Cockroaches are considered mechanical transmitters of infectious diseases, posing a threat to human health. This study assessed the potential of cockroaches in food-related environments to mechanically transmit intestinal pathogens. Cockroaches captured with traps were placed together into a low temperature refrigerator at - 80° for 2 h.

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Reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants due to immune escape is challenging for the global response to the pandemic. We estimated the Omicron reinfection prevalence among people who had a previous SARS-CoV-2 infection in Shanghai, China. We conducted a telephone survey in December 2022 with those who had previously been infected with Omicron between March and May 2022.

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Background: Seasonal influenza may overlap with the COVID-19 pandemic, and children are one of the priority populations for influenza vaccination in China, yet vaccine coverage has been low. This study aimed to investigate the extent of parental influenza vaccine hesitancy (IVH) and to explore the associated factors.

Methods: The study was conducted in Shanghai, China, from 1 June 2022 to 31 July 2022, using an anonymous questionnaire to survey a random sample of parents of children aged six months to 14 years.

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Objectives: Negative estimates can be produced when statistical modelling techniques are applied to estimate morbidity and mortality attributable to influenza. Based on the prior knowledge that influenza viruses are hazardous pathogens and have adverse health outcomes of respiratory and circulatory disease (R&C), we developed an improved model incorporating Bayes' theorem to estimate the disease burden of influenza in Shanghai, China, from 2010 to 2017.

Design: A modelling study using aggregated data from administrative systems on weekly R&C mortality and hospitalisation, influenza surveillance and meteorological data.

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The aim of this study was to thoroughly document the effects of multiple intervention and control methods to mitigate the ongoing coronavirus disease 2019 (COVID-19) outbreak in Pudong New Area, Shanghai. After identification of the first confirmed case of COVID-19 in Pudong on January 21, 2020, the local Center for Disease Control and Prevention (CDC) launched a case investigation involving isolation, close-contact (CC) tracing and quarantine of persons with a potential exposure risk to prevent and control transmission. Epidemiological features of cases detected by three different strategies were compared to assess the impact of these active surveillance measures.

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Article Synopsis
  • - Seasonal influenza vaccination rates in China are low, with only 11.8% of surveyed residents vaccinated during the 2018-2019 season; coverage is highest in children (26.6%) and lowest in the elderly (7.3%).
  • - The main reasons for not getting vaccinated include concerns about side effects (45.0%), a belief in personal health (42.2%), and lack of awareness about the vaccine (48.3%).
  • - Low education levels and a lack of awareness are significant factors contributing to the low vaccination rates, highlighting the necessity for targeted vaccination strategies in different population groups.
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International travel may facilitate the spread of the novel coronavirus disease (COVID-19). The study describes clusters of COVID-19 cases within Chinese tour groups travelling in Europe January 16-28. We compared characteristics of cases and non-cases to determine transmission dynamics.

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Background: To optimize seasonal influenza vaccination programs in regions with potentially complicated seasonal patterns, the epidemiological characteristics of seasonal influenza activity in a subtropical city of China were explored.

Materials And Methods: Influenza virus data of patients with influenza-like illness (ILI) during 2013-2019 were collected from two sentinel hospitals in a subtropical region of China, Yichang city. The influenza virus positive rate among sampled ILI cases served as a proxy to estimate influenza seasonal characteristics, including periodicity, duration, peaks, and predominant subtypes/lineages.

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Most previous studies focused on the association between climate variables and seasonal influenza activity in tropical or temperate zones, little is known about the associations in different influenza types in subtropical China. The study aimed to explore the associations of multiple climate variables with influenza A (Flu-A) and B virus (Flu-B) transmissions in Shanghai, China. Weekly influenza virus and climate data (mean temperature (MeanT), diurnal temperature range (DTR), relative humidity (RH) and wind velocity (Wv)) were collected between June 2012 and December 2018.

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Influenza vaccination is recommended for nurses in China but is not mandatory or offered free of charge. The main objective of this study was to determine influenza vaccination coverage and the principal factors influencing influenza vaccination among nurses in China. During 22 March-1 April 2018, we conducted an opt-in internet panel survey among registered nurses in China.

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Objectives: Understanding the complexity of influenza subtype seasonality is critical to promoting a suitable vaccination program. The aim of this study was to identify and compare the seasonality and epidemiological features of seasonal influenza subtypes after the 2009 A/H1N1 pandemic and to lay a foundation for further investigation into the social and environmental factors affecting seasonal influenza virus transmission.

Methods: Influenza-like illness (ILI) case surveillance was conducted in two sentinel hospitals in Pudong New Area, Shanghai between 2012 and 2018.

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Article Synopsis
  • Rotavirus is a significant cause of illness and death in young children in China, which lacks a universal vaccination program, making this study essential to understanding its prevalence and strain diversity.
  • Between 2009 and 2015, surveillance at 213 hospitals found 30% of children with diarrhea tested positive for rotavirus, with the highest cases in low-middle-income regions, especially among children aged 2 and under.
  • The study revealed a notable increase in the G9P[8] strain, demonstrating a rapid shift from older strains and emphasizing the need for ongoing rotavirus monitoring and potential vaccination efforts in the country.
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Article Synopsis
  • Older adults in China face a high risk of complications from influenza, and yearly vaccination is the best prevention method, but the vaccine is not included in the national immunization program.* -
  • A survey of 4,417 residents aged 60 and older in Shanghai revealed a very low vaccination coverage of only 5.2% during the 2016-17 season, influenced by factors like living situation and chronic health issues.* -
  • The most significant barrier to vaccination identified was a lack of awareness about the influenza vaccine, indicating the need for improved educational strategies targeting older adults.*
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More than 30 residents and nursing assistants in a geriatric nursing hospital developed acute gastroenteritis from December 7th to December 18th, 2014 in Shanghai, China. An immediate epidemiological investigation was conducted to identify the etiological agent of the outbreak, mode of transmission and the risk factors. Cases were investigated according to an epidemiological questionnaire.

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Acute respiratory infections (ARIs), with viral pathogens as the major contributors, are the most common illnesses worldwide, and increase the morbidity and mortality among the elderly population. The clinical and pathological features of elderly people with ARIs need to be identified for disease intervention. From January 1, 2012 through December 31, 2015, respiratory specimens from patients above 60 years old with ARIs were collected from the outpatient and inpatient settings of six sentinel hospitals in Pudong New Area.

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Background: Syndromic surveillance has been widely used for the early warning of infectious disease outbreaks, especially in mass gatherings, but the collection of electronic data on symptoms in hospitals is one of the fundamental challenges that must be overcome during operating a syndromic surveillance system. The objective of our study is to describe and evaluate the implementation of a symptom-clicking-module (SCM) as a part of the enhanced hospital-based syndromic surveillance during the 41st World Exposition in Shanghai, China, 2010.

Methods: The SCM, including 25 targeted symptoms, was embedded in the sentinels' Hospital Information Systems (HIS).

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