MDM2 inhibitor APG-115 synergizes with ABT-199 to induce cell apoptosis in chronic lymphocytic leukemia.

Although clinical outcomes in chronic lymphocytic leukemia (CLL) have greatly improved with several approved small molecular inhibitors, acquired resistance does occur, leading to disease progression and eventual death. Thus, the effort to explore novel inhibitors and combination therapeutic regimens is needed. The inhibition of MDM2-p53 interaction to restore p53 function has been regarded as a potential strategy for treating different cancers.

Topological MXene Network Enabled Mixed Ion-Electron Conductive Hydrogel Bioelectronics.

Mixed ion-electron conductive (MIEC) bioelectronics has emerged as a state-of-the-art type of bioelectronics for bioelectrical signal monitoring. However, existing MIEC bioelectronics is limited by delamination and transmission defects in bioelectrical signals. Herein, a topological MXene network enhanced MIEC hydrogel bioelectronics that simultaneously exhibits both electrical and mechanical property enhancement while maintaining adhesion and biocompatibility, providing an ideal MIEC bioelectronics for electrophysiological signal monitoring, is introduced.

MXene-Enabled Self-Adaptive Hydrogel Interface for Active Electroencephalogram Interactions.

Human-machine interaction plays a significant role in promoting convenience, production efficiency, and usage experience. Because of the universality and characteristics of electroencephalogram (EEG) signals, active EEG interaction is a promising and cutting-edge method for human-machine interaction. The seamless, skin-compliant, and motion-robust human-machine interface (HMI) for active EEG interaction has been in focus.

Core-shell structured SiO@ZrO@SiO filler for radiopacity and ultra-low shrinkage dental composite resins.

To overcome the interfacial problem between X-ray radiopaque ZrO fillers and polymer resin in dental composites, monodispersed SiO@ZrO@SiO (SZS) microspheres with narrow size distribution were prepared by a controlled sol-gel method. In the presence of SiO coating layer over SiO@ZrO (SZ) microspheres, they were easily silanized same as SiO microspheres. Ethoxylated bisphenol A dimethacrylate (EBPADMA) with a higher molecular weight and a lower viscosity was used as base resin monomer mixed with a low amount of diluent triethylene glycol dimethacrylate (TEGDMA).

Properties of Polylactic Acid Reinforced by Hydroxyapatite Modified Nanocellulose.

Polylactic acid (PLA) is one of the most promising bio-based materials, but its inherent hydrophobicity limits its application. Although nanocellulose (NCC) is a desirable reinforcement for PLA, the poor interface compatibility between the two has been a challenge. In this work, hydroxyapatite (HAP) modified NCC was prepared, and the obtained NCC/HAP reinforcement was used to prepare PLA/NCC-HAP composites.