Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors.

The infiltration and cytotoxicity of chimeric antigen receptor (CAR)-T cells are crucial for effective elimination of solid tumors. While metallo-immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR-T cell therapy remains elusive. The first single-element nanomaterial based on chromium nanoparticles (Cr NPs) for cancer photo-metallo-immunotherapy has been reported previously.

Self-assembled nanomaterials for synergistic antitumour therapy.

Self-assembly is a bottom-up strategy that can be used to construct a wide range of nanostructures. This review discusses the applications of self-assembled nanomaterials in the field of antitumour therapy. A variety of materials have been developed, such as nanomaterials self-assembled from polymers, biomacromolecules, proteins, peptides, inorganic materials, nucleic acids, and organic molecules, among others, and their applications include phototherapy, chemotherapy, gene therapy, imaging, immunotherapy and other fields.

Capsicum-Derived Biomass Quantum Dots Coupled with Alizarin Red S as an Inner-Filter-Mediated Illuminant Nanosystem for Imaging of Intracellular Calcium Ions.

Calcium ion (Ca) plays crucial roles in the signal transduction pathways associated with various physiological and pathological events. Monitoring intracellular Ca is of great significance for cell biology research. Here, we report the use of biomass quantum dots (BQDs) as a fluorescent reporter for imaging of intracellular Ca, based on the inner-filter-mediated luminescence which was assisted by a Ca chelator alizarin red S (ARS).

Dual functionalized natural biomass carbon dots from lychee exocarp for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy.

Photodynamic therapy (PDT) is a non-invasive phototherapy that has gained significant attention for cancer therapy. However, image-guided PDT still remains a considerable challenge. Herein, we developed a targeted, near-infrared (NIR) fluorescence imaging nanoprobe for cancer cells by preparing natural biomass carbon dots (NBCDs) from lychee exocarp, and loading transferrin and a photosensitizer on the NBCD surfaces for image-guided PDT of cancer cells and mouse tumors.

Fluorescent carbon dots with tunable emission by dopamine for sensing of intracellular pH, elementary arithmetic operations and a living cell imaging based INHIBIT logic gate.

Fluorescent carbon dots (C-dots) have drawn great attention in recent years, and many researchers have focused on developing preparation routes and broadening the applications of C-dots. In this work, novel luminescent C-dots with tunable emission were prepared by the pyrolysis of citric acid (CA) and dopamine (DA). By adjusting the molar ratio of CA and DA in the precursor from 2 : 1 to 2 : 3, the maximum fluorescence emission of the obtained C-dots is at 510 nm in acid solution, while it shifts to 450 nm under neutral conditions, and the fluorescence is quenched in a basic solution.

One-pot green synthesis of oxygen-rich nitrogen-doped graphene quantum dots and their potential application in pH-sensitive photoluminescence and detection of mercury(II) ions.

Nitrogen doping has been a powerful method to modulate the properties of carbon materials for various applications, and N-doped graphene quantum dots (GQDs) have gained remarkable interest because of their unique chemical, electronic, and optical properties. Herein, we introduce a facile one-pot solid-phase synthesis strategy for N-doped GQDs using citric acid (CA) as the carbon source and 3,4-dihydroxy-L-phenylalanine (L-DOPA) as the N source. The as-prepared N-GQDs with oxygen-rich functional groups are uniform with an average diameter of 12.