Oxidation and polymer degradation characteristics of high viscosity modified asphalts under various aging environments.

High viscosity modified asphalt (HVMA) was the core material to build ecological permeable pavement, while it was prone to aging, which limited its applications for urban sustainability. This study focused on the oxidation and polymer degradation characteristics of the high-content styrene-butadiene-styrene modified asphalt, high-viscosity composite particle modified asphalt and high-elastic modified asphalt under the simulated aging environments of thermal oxidation and weather. Gel permeation chromatography results showed that the increase percent of large molecular size percent and the decrease percent of polymer weight could characterize the oxidation degree and polymer degradation degree, respectively.

Musashi1 inhibit the release of Newcastle disease viruses through preventing apoptosis of DF-1 cells.

The efficient proliferation of Newcastle disease virus (NDV) depends on its inhibition of host cell innate immunity. V protein acts as a nonstructural protein which plays a significant role in virus replication, whereas its function remains to be further explored. In this study, Musashi RNA binding protein 1 (MSI1) was selected and its interaction with V protein was further verified by Co-immunoprecipitation (Co-IP) and Immuno-colocalization test.

Screening and mechanistic study of key sites of the hemagglutinin-neuraminidase protein related to the virulence of Newcastle disease virus.

Newcastle disease is a kind of avian infectious disease caused by Newcastle disease virus (NDV). The virulence of NDV is dependent mainly on the fusion (F) protein and hemagglutinin-neuraminidase (HN) protein. The genomes of 2 viruses, NDV-Blackbird and NDV-Dove, are 99.

Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo.

Pseudorabies virus (PRV) is an important viral pathogen of pigs that causes huge losses in pig herds worldwide. Ivermectin is a specific inhibitor of importin-α/β-dependent nuclear transport and shows antiviral potential against several RNA viruses by blocking the nuclear localization of viral proteins. Since the replication of DNA viruses is in the nucleus, ivermectin may be functional against DNA virus infections if the DNA polymerase or other important viral proteins enter the nucleus via the importin-α/β-mediated pathway.