A new perspective: Quantitative description of the Cupid's peak aesthetics essence.

Objectives: The Cupid's peak triangle theory was established to reveal the aesthetics essence of the Cupid's peak through golden ratio deviation to provide quantitative theoretical basis for lip plastic and cosmetic surgery.

Materials And Methods: Model the Cupid's peak line on the lip bow ridge and construct expressions for Cupid's peak parameters and their associated triangle theory using the angle circle (AC) and radius circle (RC) of the Cupid's peak line. Calculate and establish functional relationships for Cupid's peak parameters and the concept of the Cupid's peak index (CPI) golden ratio deviation (GRD).

Comparisons of different general anesthetic techniques on immune function in patients undergoing flap reconstruction for oral cancer.

Background: Anesthetic-induced immunosuppression is of particular interest in tumor surgery. This study aimed to investigate the influence of the 4 most common general anesthetic techniques on immune function in patients undergoing flap reconstruction for oral cancer.

Methods: 116 patients were randomly divided into 4 groups.

Developmental origin of the mammalian premaxilla.

The evolution of jaws has played a major role in the success of vertebrate expansion into a wide variety of ecological niches. A fundamental, yet unresolved, question in craniofacial biology is about the origin of the premaxilla, the most distal bone present in the upper jaw of all amniotes. Recent reports have suggested that the mammalian premaxilla is derived from embryonic maxillary prominences rather than the frontonasal ectomesenchyme as previously shown in studies of chicken embryos.

Soft Palate Dysplasia: Properties and Surgical Techniques.

Background: The authors aimed to report a hitherto undescribed class of patients with the obvious phenotype of a novel soft palate dysplasia (SPD) combining unilateral soft palate hypoplasia with a fully developed uvula. The authors also aimed to investigate and evaluate the corresponding surgical approaches.

Methods: Twelve patients were clinically diagnosed with SPD.

A WAP-Based Concept Acquisition Teaching Model in Cleft Lip and Palate Phenotype and Embryonic Development: Functionality and Usability Study.

Objective: Taking advantage of the broad coverage of Wireless Application Protocol (WAP), we developed a Content Management System (CMS)-programmed mobile learning application. This application can help the undergraduate to obtain a comprehensive understanding of concepts in Cleft lip and palate Phenotype, and Embryonic development (CPE). The present study aims to evaluate the feasibility and efficacy of the concept acquisition teaching model on the basis of WAP in a practical undergraduate course of CPE.

A Comparison of Dexmedetomidine and Propofol on Emergence Delirium in Children Undergoing Cleft Palate Surgery With Sevoflurane-Based Anesthesia.

Emergence delirium is a common complication after sevoflurane-anesthesia and have a serious impact on children undergoing cleft palate surgery. The aim of this study was to compare the effect of propofol and dexmedetomidine on emergence delirium in children. Ninety children aged 8 to 24 months, underwent cleft palate repair, were enrolled in the study.

Effects of dexmedetomidine on immune response in patients undergoing radical and reconstructive surgery for oral cancer.

Oral cancer is one of the most common malignancies in the world. The present study aimed to investigate the effects of dexmedetomidine on immune response in patients undergoing radical and reconstructive surgery for oral cancer. Patients were randomly divided into the dexmedetomidine and control groups.

Novel IRF6 mutations in Chinese Han families with Van der Woude syndrome.

Background: Interferon Regulatory Factor 6 (IRF6) gene encodes a member of the IRF family of transcription factors. Mutations in IRF6 cause Van der Woude Syndrome (VWS), which is the most common malformation of syndromic orofacial clefts in humans.

Methods: Here, we performed sequencing studies of six families with VWS in the Chinese Han population.

Quantitative assessment of the relationship between Fas/FasL genes polymorphisms and head and neck cancer risk.

Background: Molecular epidemiological studies have demonstrated a closer association between Fas/FasL polymorphisms and head and neck cancer (HNC) risk, and the results of these published studies were inconsistent. We therefore performed this meta-analysis to explore the associations between Fas/FasL polymorphisms and HNC risk.

Methods: Four online databases (PubMed, Embase, CNKI, and Wanfang) were searched.

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.

Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in humans. Here we conduct a GWAS of NSCLP with multiple independent replications, totalling 7,404 NSOFC cases and 16,059 controls from several ethnicities, to identify new NSCLP risk loci, and explore the genetic heterogeneity between sub-phenotypes of NSOFC. We identify 41 SNPs within 26 loci that achieve genome-wide significance, 14 of which are novel (RAD54B, TMEM19, KRT18, WNT9B, GSC/DICER1, PTCH1, RPS26, OFCC1/TFAP2A, TAF1B, FGF10, MSX1, LINC00640, FGFR1 and SPRY1).

A novel initiation codon mutation of PAX9 in a family with oligodontia.

Objective: Recent studies have attributed non-syndromic tooth agenesis to mutations in several genes, including MSX1, PAX9, AXIN2, WNT10A and EDA. In this study, mutation of PAX9gene was investigated in a four-generation Chinese family with oligodontia.

Design: Genomic DNA was isolated from the blood samples of all the available family members.

Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.

Objective: To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.

Methods: Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.

[A follow-up study on velopharyngeal airway condition post pharyngoplasty].

Objective: To observe changes in velopharyngeal airway condition post pharyngoplasty.

Methods: Thirty-five patients underwent sphincter pharyngoplasty (SPP) or pharyngeal flap (PF). The follow-up period was approximately six months.