Polyhydroxyalkanes from Sieb. et Zucc.

Four polyhydroxyalkanes were isolated from the CHCl part of , including two new ones, (2,3)-3-isopropylpent-3-ene-1,2,5-triol () and (4,2)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (); as well as one new natural product, 3-methylbut-3-ene-1,2-diol () and one known compound, 4-methyl-3-methylenepentane-1,2-diol (). The structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS, and ECD data. The cytotoxic activity of compounds against the human cancer lines A549, H460, and HepG2 cell lines of the isolated compounds was evaluated by the CCK8 method.

The Sources, Structures and Cytotoxicity of Animal-Derived Bisindole Compounds.

Bisindole compounds constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the past four decades, researchers have isolated 229 animal-derived bisindole compounds (ADBCs) from various animals. These compounds demonstrate a wide range of pharmacological properties, including cytotoxicity, antibacterial, antifungal, antiviral, and other activities.

[The expression of scavenger receptor class A in the lung in mice with acute lung injury induced by lipopolysaccharide].

Objective: To investigate the expression of scavenger receptor class A (SR-A) in lung tissue and alveolar macrophage (AM) in mice with acute lung injury (ALI) induced by lipopolysaccharide (LPS).

Methods: The model of ALI was reproduced by intraperitoneal (ip) injection of LPS (5 mg/kg), and the expression of SR-A was observed in lung tissue and AM, and the expression and distribution of J774 A.1 were also studied by using mouse macrophage line.