WTAP promotes proliferation of esophageal squamous cell carcinoma via mA-dependent epigenetic promoting of PTP4A1.

Esophageal squamous cell carcinoma (ESCC) represents a frequently seen malignancy with high prevalence worldwide. Although current studies have shown that Wilms' tumor 1-associated protein (WTAP), a major part in the methyltransferase complex, is involved in various tumor pathological processes, its specific role in ESCC remains unclear. Therefore, the present work focused on exploring WTAP's function and mechanism in ESCC progression using clinical ESCC specimens, ESCC cells, and mammalian models.

Acoustic emission characteristics of micro-discharges in initial pulsed PEO process on 60% SiC/Al composite.

The initial discharge process of pulsed plasma electrolytic oxidation (PEO) on the 60% SiC/2009 aluminum metal matrix composite (Al MMC) in silicate solution was monitored by acoustic emission (AE) technique. Parameters and correlations of AE signals on the Al MMC sample and under water were analyzed, and their generation mechanism was discussed. It was found that the peak amplitudes of AE signals and AE hits during the pulse time quickly increased with the increase of micro-discharge intensity, and the absolute energy of AE signals improved several orders of magnitude.

In situ monitoring of initial plasma electrolytic oxidation process on 60 vol. % SiCp/2009 aluminum matrix composite by sound and vibration measurement techniques.

The initial discharge process of plasma electrolytic oxidation (PEO) on the 60 vol. % SiCP/2009 aluminum matrix composite in silicate solution was in situ monitored by sound and vibration measurement techniques. The underwater sound, airborne sound, and sample vibration signals were detected in the initial 120 s of the PEO process, and their generation mechanism was discussed.

TPP1 Inhibits DNA Damage Response and Chemosensitivity in Esophageal Cancer.

TPP1, as one of the telomere-protective protein complex, functions to maintain telomere stability. In this study, we found that TPP1 was significantly upregulated in esophageal cancer (EC). We found that the proliferation and migration ability were significantly inhibited, while the results of flow cytometry assay indicated that the growth was hindered in the G1 phase after TPP1 knockdown.

Comprehensive Analysis of Potential Correlation Between Solute Carrier 1A (SLC1A) Family and Lung Adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is the most common dangerous malignant tumor and the leading cause of global cancer incidence and mortality. The Solute Carrier 1A (SLC1A) family play a significant part in cellular biological process, inflammation, and immunity. Specific functions of the SLC1A family in lung cancer are still not systematically described.

Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer.

To elucidate the oncogenic role of human telomerase reverse transcriptase (hTERT) in esophageal squamous cancer and unravel the therapeutic role and molecular mechanism of dihydroartemisinin (DHA) by targeting hTERT. The expression of hTERT in esophageal squamous cancer and the patients prognosis were analyzed by bioinformatic analysis from TCGA database, and further validated with esophageal squamous cancer tissues in our cohort. The Cell Counting Kit-8 (CCK8) and colony formation assay were used to evaluate the proliferation of esophageal squamous cancer cell lines (Eca109, KYSE150, and TE1) after hTERT overexpression or treated with indicated concentrations of DHA.