Recombinant human erythropoietin improves functional recovery in patients with severe traumatic brain injury: A randomized, double blind and controlled clinical trial.

Objective: To investigate the short-term effect of recombinant human erythropoietin (EPO) on patients with severe traumatic brain injury.

Methods: One hundred and fifty-nine patients with severe traumatic brain injury were randomly divided into EPO (n=79) and control group (n=80). EPO group was treated with subcutaneous injection of EPO (100 units/kg) on day 1, 3, 6, 9 and 12 following the brain injury.

Potential Diagnostic and Prognostic Value of Plasma Circulating MicroRNA-182 in Human Glioma.

Background: Previous studies showed the aberrant expression of microRNA-182 (miR-182) in glioma tissue. However, the exact role of circulating miR-182 in glioma remains unclear. Here, we confirmed the expression of plasma circulating miR-182 in glioma patients, and further explored its potential diagnostic and prognostic value.

Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage-a prospective clinical observation.

Background: This study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).

Methods: One hundred patients were divided into a study (n=60) or a control group (n=40). Bone marrow mononuclear cells from the same patient were injected to the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.

[Treatment of recurrent malignant gliomas by surgery combined with recombinant adenovirus-p53 injection].

Objective: To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant adenovirus-p53 injection of recurrent malignant gliomas.

Methods: 38 patients with recurrent malignant gliomas were included in this study. Among them, 18 patients of combined treatment group had Ommaya reservoirs placed into the tumor cavities after the resection of the tumors and received regular recombinant adenovirus-p53 injections after the operation.

[Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma].

Objective: To evaluate the treatment results of stereotactic (186)Re intracavitary irradiation in the patients with craniopharyngioma.

Methods: Nineteen patients were treated with stereotactic (186)Re intracavitary irradiation, including 12 males and 7 females (average age, 37.2 years).

Consciousness and speech evaluation of 96 patients with craniocerebral injury.

Objective: To explore the effective methods for evaluating the consciousness and speech status of patients with special types of cerebral injuries.

Methods: A total of 96 patients with injury in the language center and in coma were treated with operative and correlated conventional therapies. Then their recovery status of consciousness and speech was observed.