Jin-Gu-Lian Capsule Did Not Significantly Improve Clinical Value in Rheumatoid Arthritis Therapy: A Real-World Study.

Purpose: To investigate the clinical value of adding Jin-gu-lian (JGL) capsules into rheumatoid arthritis (RA) treatment by examining its impact on disease activity and quality of life (QoL) through a real-world study (RWS).

Patients And Methods: RWS was conducted to compare the inflammatory markers, including IgM-RF, ESR, and CRP, between RA patients treated with only Western medicine (reference group) and Western medicine plus JGL (study group) during one-year follow-up. The clinical data was acquired from the hospital information system (HIS).

The prevalence and characteristics of frailty in cirrhosis patients: a meta-analysis and systematic review.

Objectives: This study aimed to assess the prevalence of frailty in cirrhosis patients and the distribution of age, sex, and body mass index (BMI) in cirrhotic patients with frailty.

Methods: We performed a thorough literature search using PubMed, Embase, Web of Science, and the Cochrane Library from inception to 29 February 2024. The estimated prevalence with a 95% confidence interval (CI) was calculated with a random effect model.

Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods.

Crohn's disease (CD) is a complex autoimmune disorder presumed to be driven by complex interactions of genetic, immune, microbial and even environmental factors. Intrinsic molecular mechanisms in CD, however, remain poorly understood. The identification of novel biomarkers in CD cases based on larger samples through machine learning approaches may inform the diagnosis and treatment of diseases.

A retrospective cohort study of intensive gastric variceal ligation versus endoscopic gastric variceal obturation in the management of gastric variceal bleeding.

Background: Gastric variceal bleeding is often more serious and can be fatal. Currently, international consensus recommendations for the treatment of gastric variceal bleeding vary according to endoscopic classification. Few studies have investigated ligation versus gastric variceal obturation (GVO) for the treatment of gastric varices.

Identification of a Ferroptosis-Related Signature Model Including mRNAs and lncRNAs for Predicting Prognosis and Immune Activity in Hepatocellular Carcinoma.

Background: Ferroptosis is a novel form of regulated cell death involved in tumor progression. The role of ferroptosis-related lncRNAs in hepatocellular carcinoma (HCC) remains unclear.

Methods: RNA-seq and clinical data for HCC patients were downloaded from The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal.

Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic, complicated, inflammatory disease with an increasing incidence and prevalence worldwide. However, the intrinsic molecular mechanisms underlying the pathogenesis of UC have not yet been fully elucidated. All UC datasets published in the GEO database were analyzed and summarized.

Influence of conservation tillage on Greenhouse gas fluxes and crop productivity in spring-wheat agroecosystems on the Loess Plateau of China.

The effects of climate change such as dry spells, floods and erosion heavily impact agriculture especially smallholder systems on the Northwestern Loess Plateau of China. Nonetheless agriculture also contributes to global warming through the emission of greenhouse gases such as CO, CH and NO. Yet this complex conundrum can be alleviated and mitigated through sound soil and water management practices.

Overexpression of the immediate early response 5 gene increases the radiosensitivity of HeLa cells.

The effects of the immediate early response 5 () gene on the sensitivity of HeLa cells to radiation remain unclear. In the present study, stably transfected HeLa cells resulting in the knockdown or overexpression of were investigated. In addition, xenografts of normal, -silenced and -overexpressed HeLa cells were injected into nude mice and examined.

Enhanced phytoremediation of cadmium and/or benzo(a)pyrene contaminated soil by hyperaccumlator Solanum nigrum L.

The role of same amendment on phytoremediating different level contaminated soils is seldom known. Soil pot culture experiment was used to compare the strengthening roles of cysteine (CY), EDTA, salicylic acid (Sa), and Tween 80 (TW) on hyperaccumulator Solanum nigrum L. phytoremediating higher level of single cadmium (Cd) or Benzo(a)pyrene (BAP) and their co-contaminated soils.

IER5 promotes irradiation- and cisplatin-induced apoptosis in human hepatocellular carcinoma cells.

Purpose: To elucidate the mechanisms of the immediate-early response gene 5 (IER5) effect on the apoptosis induced by irradiation and cisplatin (CDDP) in human hepatocellular carcinoma (HepG2) cells.

Methods: We generated IER5 overexpression stable cells (HepG2/IER5) using Lipofectamine 2000 transfection HepG2 cells. Cell apoptosis was induced by irradiation and cisplatin treatments, and cell proliferation (viability) and apoptosis were evaluated by MTT and flow cytometry assays.

NU7441 Enhances the Radiosensitivity of Liver Cancer Cells.

Objective: Radiation therapy, one of the major treatments for liver cancer, causes DNA damage and cell death. Since the liver cancer cells have a strong capacity to repair irradiative injury, new medicines to enhance this treatment are urgently required. In this study, we investigated the effect of NU7441, a synthetic small-molecule compound, as a specific inhibitor of DNA-dependent protein kinase (DNA-PK) in radiosensitization of hepatocellular carcinoma HepG2 cells.

Compound amino acids added in media improved Solanum nigrum L. phytoremediating CD-PAHS contaminated soil.

Cd hyperaccumulator Solanum nigrum L. was a promising plant used to simultaneously remediate Cd-PAHs combined pollution soil through its extra accumulation capacity and rhizosphere degradation. This article compared the strengthening remediation role of cysteine (Cys), glycine (Gly) and glutamic acid (Glu) with EDTA and TW80.

Chemical-assisted phytoremediation of CD-PAHs contaminated soils using Solanum nigrum L.

A well-characterized cadmium (Cd) hyperaccumulating plant Solanum nigrum was grown in Cd and polycyclic aromatic hydrocarbons (PAHs) co-contaminated soil that was repeatedly amended with chemicals, including EDTA, cysteine (CY), salicylic acid (Sa), and Tween 80 (TW80), to test individual and combined treatment effects on phytoremediation of Cd-PAHs contaminated soils. Plant growth was negatively affected by exogenous chemicals except for EDTA. S.

[Effects of illumination and seed-soaking reagent on seed germination of Solanum nigrum].

To explore a rapid seed germination method for hyperaccumulator Solanum nigrum, a germination experiment with different illumination and seed-soaking treatments was conducted in constant temperature box and greenhouse, with filter as burgeon base. Under illumination, the germination rate was about 5 times high of that without illumination (P < 0.05), indicating that illumination was one of the prerequisites for the seed germination of S.

Induced expression of the IER5 gene by gamma-ray irradiation and its involvement in cell cycle checkpoint control and survival.

The immediate-early response gene 5 (IER5) was previously shown, using microarray analysis, to be upregulated by ionizing radiation. Here we further characterized the dose- and time-dependency of radiation-induced expression of IER5 at doses from 0.5 to 15 Gy by quantitative real-time PCR analyses in HeLa cells and human lymphoblastoid AHH-1 cells.

[Hyperaccumulative characteristics of 7 widely distributing weed species in composite family especially Bidens pilosa to heavy metals].

Hyperaccumulator is the main point of phytoremediating contaminated soils by heavy metals, and the identification of hyperaccumulator is still the difficult and key step of phytoremediation. The outdoor pot-culture experiment was used to study the hyperaccumulative characteristics of 7 widely distributing weed species in Northeast of China to heavy metals. The results in screening experiment showed that Taraxacum mongolicum and Bidens pilosa indicated strong tolerance to Cd single and Cd-Pb-Cu-Zn combined pollution, their Cd concentration in shoot were higher than that in roots, and the Cd enhancement factors (ratio of heavy metal concentration in shoot to that in soil) in shoots were greater than 1 too, which displayed that the two plants were with Cd hyperaccumulative characteristics.

Kalimeris integrifolia Turcz. ex DC.: an accumulator of Cd.

Phytoremediation is a traditional technique that uses vegetation to remediate contaminants from water, soil and sediments. This is a solar-driven, aesthetically pleasing, and cost effective technology. In a former published article, Kalimeris integrifolia Turcz.

Hyperaccumulative property comparison of 24 weed species to heavy metals using a pot culture experiment.

The screening of hyperaccumulators is still very much needed for phytoremediation. With properties such as strong tolerance to adverse environment, fast growing and highly reproductive rate, weed species may be an ideal plant for phytoremediation. The objectives of this study were to examine the tolerance and hyperaccumulative characteristics of 24 species in 9 families to Cd, Pb, Cu and Zn by using the outdoor pot-culture experiment.

[Effects of ET-1 on isolated perfused rat liver and vascular rings at two stages of cirrhosis].

Objective: To investigate the effects of ET-1 on isolated perfused rat liver and vascular rings at early and late stages of cirrhosis.

Methods: Liver cirrhosis was induced by an intraperitoneal injection of 50% CCl(4) (0.3 ml/100 g, twice a week).