Downregulation of homeobox B8 in attenuating non-small cell lung cancer cell migration and invasion though the epithelial-mesenchymal transition pathway.

Background: Homeobox ) family genes have been identified as regulators of cancer development. No research exists concerning the mechanisms underlying homeobox B8 () activity in non-small cell lung cancer (NSCLC). In this study, we investigated expression and biological function in NSCLC to determine whether it is an important marker of patient prognosis.

Sequential Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Induced Radical Surgery in Oligometastatic Non-Small Cell Lung Cancer: A Case Report.

Sequential regimens in patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) can overcome tyrosine kinase inhibitor (TKI) resistance and maximize clinical benefit. Patients with advanced NSCLC can achieve excellent tumor control after a period of EGFR-TKI treatment. Patients may benefit from additional local treatment, such as surgery or radiation therapy, once the tumor is under control.

Personalized treatment of extensive stage small cell lung cancer: A case report and literature review.

A 50-year-old female patient presented with post-exercise dyspnea in September 2016, and was subsequently diagnosed with SCLC with multiple brain and spinal metastases. The first-line treatment was etoposide combined with cisplatin and synchronously performed radiotherapy for the brain and spinal cord metastases. She was treated with anlotinib after disease progression in December 2018 and continued to have clinical benefit for nearly 25 months.

Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.

Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations.

Engineering Lateral Heterojunction of Selenium-Coated Tellurium Nanomaterials toward Highly Efficient Solar Desalination.

Herein, a core-shell tellurium-selenium (Te-Se) nanomaterial with polymer-tailed and lateral heterojunction structures is developed as a photothermal absorber in a bionic solar-evaporation system. It is further revealed that the amorphous Se shell surrounds the crystalline Te core, which not only protects the Te phase from oxidation but also serves as a natural barrier to life entities. The core (Te)-shell (Se) configuration thus exhibits robust stability enhanced by 0.

High-Performance Humidity Sensor Based on Urchin-Like Composite of TiC MXene-Derived TiO Nanowires.

Humidity sensors have broad applications in health monitoring, environmental protection and human-machine interface, and robotics. Here, we developed a humidity sensor using alkali oxidation method to grow in situ TiO nanowires on two-dimensional TiC MXene. With an order of magnitude larger surface area compared to pure TiC or TiO materials, the urchin-like TiC/TiO composite demonstrates a record high sensitivity in a low relative humidity (RH) environment (∼280 pF/% RH from 7% RH to 33% RH).

Probing Liquid-Solid and Vapor-Liquid-Solid Interfaces of Hierarchical Surfaces Using High-Resolution Microscopy.

Liquid-solid (LS) and vapor-liquid-solid (VLS) interfaces are important for the fundamental understanding of how surface chemistry impacts industrial processes and applications. Superhydrophobic surfaces, from structural hierarchies, were fabricated by coating flat smooth surfaces with hollow glass microspheres. These surfaces are referred to as structural hierarchical-modified microsphere surfaces (SHiMMs).

Experimental realization of coherent perfect polarization rotation.

Coherent perfect processes enable high optical efficiencies in optical conversion phenomena such as coherent perfect absorption or coherent perfect polarization rotation. A linear optical coherent perfect process based on Faraday rotation has been evaluated experimentally, achieving contrast limited by other optical components of the system and demonstrating like-parity resonance doublets above threshold.

Chromatic control in coextruded layered polymer microlenses.

We describe the formation, characterization and theoretical understanding of microlenses comprised of alternating polystyrene and polymethylmethacrylate layers produced by multilayer coextrusion. These lenses are fabricated by photolithography, using a grayscale mask followed by plasma etching, so that the refractive index alternation of the bilayer stack appears across the radius of the microlens. The alternating quarter-wave thick layers form a one-dimensional photonic crystal whose dispersion augments the material dispersion, allowing one to sculpt the chromatic dispersion of the lens by adjusting the layered structure.

Ultracompact beam splitters based on plasmonic nanoslits.

An ultracompact plasmonic beam splitter is theoretically and numerically investigated. The splitter consists of a V-shaped nanoslit in metal films. Two groups of nanoscale metallic grooves inside the slit (A) and at the small slit opening (B) are investigated.

Photo-pens: a simple and versatile tool for maskless photolithography.

We demonstrate conical pores etched in tracked glass chips for fabricating patterns at the micrometer scale. Highly fluorescent patterns based on photopolymerization of diacetylene films were formed by irradiating UV light through conical pores called "photo-pens". The properties of photopens were investigated through experiments, finite-difference-time-domain (FDTD) simulations and numerical calculations based on Fresnel equations.