Targeting long non-coding RNA H19 in Subchondral Bone Osteocytes Alleviates Cartilage Degradation in Osteoarthritis.

Introduction: Emerging evidence suggests long non-coding RNA (lncRNA) H19 is associated with osteoarthritis (OA) pathology. However, how H19 contributes to OA has not been reported. This study aims to investigate the biological function of H19 in OA subchondral bone remodeling and OA progression.

Effect of Coal Particle Size on the Kinetics of Gas Hydrate Formation.

Coal and gas outbursts are one of the main factors that restrict access to high-quality coal, and the adoption of gas hydration solidification technology is expected to reduce the chance of such accidents. In this study, experiments were conducted on the kinetics of CH and CO hydrate formation in four coal particle size systems (C1:0.425-0.

Raman Spectroscopy Study on Ternary Model Coal Mine Methane Hydrates.

The microfeatures of coal mine methane (CMM) hydrates, synthesized with three gas samples (CH/CH/N, G1 = 43 : 47 : 10, G2 = 60 : 30 : 10, and G3 = 74 : 16 : 10) in a self-made transparent high-pressure cell at 275.15 K and 5 MPa were investigated using Raman spectroscopy. As a discriminator, the vibrational band frequencies in the C-C regions of the recorded hydrate Raman spectra for CH show that G1∼G3 hydrates are structure I.

Kinetics of Hydrate Formation and Dissociation in Coal at Different Temperatures Based on Impedance Method.

In the process of coal mining, gas outburst is a challenge that must be prevented to guarantee mining safety. Forming gas hydrate in coal can reduce the original gas pressure and delay the concentrative outbursts of gas flow, which is one of the potential technologies to prevent gas outbursts in coal. In this work, we perform the formation and dissociation kinetics experiment of hydrate in the presence of coal and tetrahydrofuran (THF) at the temperature based on different geological conditions in China by means of the experimental device with the impedance measurement function.

Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction.

The present study was aimed to examine whether icariin, a traditional Chinese medicine, could improve therapeutic effects of adipose derived mesenchymal stem cells (ADSCs) for diabetes-associated erectile dysfunction (DMED). DMED were induced in rats by intraperitoneal injection of streptozotocin and confirmed by erectile function measurement. Then, rats of diabetic ED were randomly divided to receive the treatment of saline, ADSCs, icariin or ADSCs combined with icariin respectively.

Multi-locus Test and Correction for Confounding Effects in Genome-Wide Association Studies.

Genome-wide association studies (GWAS) examine a large number of genetic variants, e. g., single nucleotide polymorphisms (SNP), and associate them with a disease of interest.

Impact of obesity upon prostate cancer-associated mortality: A meta-analysis of 17 cohort studies.

A number of epidemiological studies have suggested that obesity is associated, albeit inconsistently, with the incidence of prostate cancer (PCa). In order to provide a quantitative assessment of this association, the present study examined the correlation between obesity and the incidence and associated mortalities of PCa in an updated meta-analysis of cohort studies. The cohort studies were identified by searching the EMBASE and MEDLINE databases on January 1, 2014.

[Raman spectroscopic studies on CO2-CH4-N2 mixed-gas hydrate system].

Accurate determination of coal mine gas separation product characteristics is the key for gas separation application based on hydrate technology. Gas hydrate was synthesized from two types of gas compositions (CO2-CH4-N2). The separation products were measured by in situ Raman spectroscopy.