Publications by authors named "Chuangzhi Kang"
Background: is used in traditional Chinese medicine, so ensuring an adequate supply of plant material with high levels of bioactive components is important.
Methods: Using an optimized maximum entropy niche model and assays of bioactive components from cultivation samples, this study started from the plant's natural distribution area and estimated correlations of ecological factors with not only abundance of the plant but also abundance of polysaccharides and heterophyllin B. These correlations were combined with the spatial analysis function in ArcGIS to generate maps of the suitability of different habitats in China for cultivating under current climate conditions and different models of climate change.
Article Synopsis
- Chronic exposure to aflatoxin B1 (AFB1) in mice significantly worsens stress vulnerability, as seen through various behavioral tests, when combined with chronic mild stress (CMS).
- Morphological changes in microglia were observed, including an increase in pyroptosis markers in the hippocampus of AFB1-treated mice, indicating inflammation and cell death.
- Additionally, AFB1 exposure led to decreased neurogenesis in the hippocampus, with fewer proliferating neural stem cells, further exacerbated by the presence of chronic mild stress.