Trojan-Like Peptide Drug Conjugate Design and Construction for Application in Treatment of Triple-Negative Breast Cancer.

Clinical treatment of triple negative breast cancer (TNBC) is very poor for lack of effective treatment combination selection. Protein C receptor (PROCR) is a novel cancer stem marker in TNBC patients tumor tissues. Developed based on peptide BP10 with affinity to PROCR as a targeting element, constructing a peptide drug conjugate of BP10 covalently coupling doxorubicin with disulfide bonds.

Luteolin-Loading Her-2 Nanospheres Enhances Targeting and Therapeutic Effects of Breast Cancer.

Despite the broad anticancer activity, whereas the clinical application of luteolin is hindered by unsatisfactory water solubility and non-targeting. Herein, targeted inhibitory effects of luteolin-loading HER2 nanospheres (Her-2-NPs) were successfully prepared by thin film ultrasonic method. In comparison with the non-targeted nanospheres, Her-2 nanospheres could significantly boost the intake of luteolin in SK-BR-3 cells.

Correction to: Prognostic biomarkers related to breast cancer recurrence identified based on Logit model analysis.

An amendment to this paper has been published and can be accessed via the original article.

Prognostic biomarkers related to breast cancer recurrence identified based on Logit model analysis.

Background: This study intended to determine important genes related to the prognosis and recurrence of breast cancer.

Methods: Gene expression data of breast cancer patients were downloaded from TCGA database. Breast cancer samples with recurrence and death were defined as poor disease-free survival (DFS) group, while samples without recurrence and survival beyond 5 years were defined as better DFS group.

Computerized Image Analysis to Differentiate Benign and Malignant Breast Tumors on Magnetic Resonance Diffusion Weighted Image: A Preliminary Study.

Purpose: This work aims to determine the feasibility of using a computer-aided diagnosis system to differentiate benign and malignant breast tumors on magnetic resonance diffusion-weighted image (DWI).

Materials And Methods: Institutional review board approval was obtained. This retrospective study included 76 patients who underwent breast magnetic resonance imaging before neoadjuvant chemotherapy from March 10, 2017, to October 12, 2017, with a total of 80 breast tumors including 40 cases of breast cancers and 40 cases of benign breast tumors.

Identification of potential serum biomarkers for breast cancer using a functional proteomics technology.

Background: Cancer is a genetic disease; its development and metastasis depend on the function of many proteins. Human serum contains thousands of proteins; it is a window for the homeostasis of individual's health. Many of the proteins found in the human serum could be potential biomarkers for cancer early detection and drug efficacy evaluation.