A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice.

Objective: To explore a more effective and practical comprehensive index for differentiating benign from malignant obstructive jaundice by analyzing the clinical data of patients with benign obstructive jaundice (BJ) group and malignant obstructive jaundice (MJ) group.

Methods: A retrospective analysis was conducted on the clinical data of 339 patients with obstructive jaundice. The cases were divided into two data sets: training cohort and validation cohort.

A newly identified secretory phospholipase A2 group XIIA homolog (LcPLA2XIIA) in Larimichthys crocea exhibits antimicrobial and antitumor activities.

The phospholipase A2 (PLA2) superfamily has attracted increasing attention in recent years due to the multiple physiological and pathological functions exerted by its members. Up to date, the knowledge about the biological role of PLA2XIIA subfamily members remains limited. In this study, a new member of PLA2XIIA subfamily, LcPLA2XIIA, was characterized in large yellow croaker.

Comparative transcriptomic analysis of hepatopancreas reveals that more genes are involved in the exposure response of Vibrio parahaemolyticus PirA compared to PirB.

Vibrio parahaemolyticus (VP-) is regarded as one of the main pathogens that caused acute hepatopancreatic necrosis disease (AHPND) in the Pacific white shrimp Litopenaeus vannamei. PirA and PirB toxin proteins are the main pathogenic proteins of AHPND in shrimp. Knowledge about the mechanism of shrimp response to PirA or PirB toxin is very helpful for developing new prevention and control strategy of AHPND in shrimp.

Analysis of the Expression and Prognostic Value of SIRTs in Hepatocellular Carcinoma.

Purpose: This study contributes to the evolving understanding of the pivotal involvement of Sirtuins (SIRTs) in various human cancers, with a particular focus on elucidating their expression patterns and clinical relevance within the context of hepatocellular carcinoma (HCC). The investigation involves a comprehensive analysis of mRNA expression and prognostic implications associated with distinct SIRTs in HCC.

Patients And Methods: Initial data pertaining to SIRT expression in HCC patients were collated from publicly accessible databases.

Anthropogenic short-lived halogens increase human exposure to mercury contamination due to enhanced mercury oxidation over continents.

Mercury (Hg) is a contaminant of global concern, and an accurate understanding of its atmospheric fate is needed to assess its risks to humans and ecosystem health. Atmospheric oxidation of Hg is key to the deposition of this toxic metal to the Earth's surface. Short-lived halogens (SLHs) can provide halogen radicals to directly oxidize Hg and perturb the budget of other Hg oxidants (e.

Control of fine particulate nitrate during severe winter haze in "2+26" cities.

The "2+26" cities, suffering the most severe winter haze pollution, have been the key region for air quality improvement in China. Increasing prominent nitrate pollution is one of the most challenging environmental issues in this region, necessitating development of an effective control strategy. Herein, we use observations, and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO-NO-VOC-NH emission control on nitrate pollution mitigation in "2+26" cities.

A novel C-type lectin (SpccCTL) suppresses MCRV replication by binding viral protein and regulating antiviral peptides in Scylla paramamosain.

Pattern recognition receptors (PRRs) play a crucial role in the recognition and activation of innate immune responses against invading microorganisms. This study characterizes a novel C-type lectin (CTL), SpccCTL. The cDNA sequence of SpccCTL has a full length of 1744 bp encoding a 338-amino acid protein.

A Research on Accident Reconstruction of Bus-Two-Wheeled Vehicle Based on Vehicle Damage and Human Head Injury.

The problem of large calculation models in bus-two-wheeled vehicle traffic accidents (TA) leads to the difficulty of balancing the calculation efficiency and accuracy, as well as difficulties in accident reconstruction. Herein, two typical accidents were reconstructed, based on the rigid-flexible coupled human model (HM) and the Facet vehicle model, and the vehicle damage conditions and the human head biomechanical injury were analyzed. The simulation results showed that the physical process of the human-vehicle collision was basically consistent with the accident video, the windshield fracture was consistent with the actual vehicle report, and the human biomechanical injury characteristics were also consistent with the autopsy report, which verified the feasibility of the simulation model, and provides a basis and reference for forensic identification and for traffic police to deal with accident disputes.

Incidence trends of acute viral hepatitis caused by four viral etiologies between 1990 and 2019 at the global, regional and national levels.

Background: Hepatitis is a major public health challenge and a leading cause of death worldwide. We aimed to study the cause-specific incidence and temporal trends of acute viral hepatitis (AVH).

Methods: Data on AVH etiologies were available from the Global Burden of Disease study 2019.

Predictive effects of preoperative serum CA125 and AFP levels on post-hepatectomy survival in patients with hepatitis B-related hepatocellular carcinoma.

The association between the serum levels of cancer antigen 125 (CA125; also termed MUC16) and the prognosis of patients with hepatocellular carcinoma (HCC) has not been widely reported to date. The aim of the present study was to determine the association between preoperative serum CA125 levels and prognosis of patients with hepatitis B virus (HBV)-related HCC after hepatectomy. The study included 306 patients with HBV-related HCC who underwent liver resection and were classified into four subgroups based on their baseline CA125 and α-fetoprotein (AFP) levels.

Spatio-temporal distribution of six pollutants and potential sources in the Hexi Corridor, Northwest China.

Particulate matter (PM) concentrations are affected by anthropogenic emissions and sand transport jointly; however, the relative contributions from those two aspects are usually unknown. In our work, statistical analysis and back trajectories model were used to identify the dominant source in such area, by taking Yumen City as an example. We come to the conclusion that local emissions dominate the concentration of airborne pollutants, while sand transport plays a significant role on PM concentration.

[Ferumoxide labeled Flk1+ CD31- CD34- human bone marrow mesenchymal stem cells and its in vivo tracing in the brains of Macaca Fascicularis].

Objective: To explore the method for labeling Flk1+ CD31- CD34- human bone marrow mesenchymal stem cells (hBMSCs) with ferumoxide-PLL and evaluate the feasibility of its tracing after transplantation into the brains of Macaca Fascicularis.

Methods: The hBMSCs were incubated with ferumoxide-PLL. Trypan blue staining, Prussian blue staining, and transmission electron microscope were performed to show intracellular iron, marking efficiency, and the vigor of the labeled cells.