Insights into the formation of pullulan nanofilm and its feasibility as probiotic-resided oral fast dissolving carrier.

Oral fast dissolving films represent a novel dosage form for probiotics. To reduce the dependence of film preparation on synthetic materials, a polysaccharide-based oral fast dissolving nanofilm for probiotics was fabricated through pullulan (PUL) electrospinning. An electrospinnability map of PUL with varying physical properties was developed, identifying a molecular weight of 200 kDa and a concentration of 20 % as suitable conditions for achieving favorable fiber morphology.

Electrospinning and Electrospraying: Emerging Techniques for Probiotic Stabilization and Application.

Probiotics are beneficial for human health. However, they are vulnerable to adverse effects during processing, storage, and passage through the gastrointestinal tract, thus reducing their viability. The exploration of strategies for probiotic stabilization is essential for application and function.