Publications by authors named "Chuancheng Yang"

Article Synopsis
  • - Histamine plays a key role in various bodily functions like allergic reactions, wakefulness, and gastric acid secretion, and it works through four different histamine receptors.
  • - The study analyzes 9 cryo-electron microscopy structures of these receptors bound to different G protein types and agonists, revealing important details about how histamine binds and the nuanced differences in receptor interactions.
  • - Findings include specific motifs for ligand recognition and key residues for selectivity, providing a framework for designing targeted drugs that can effectively interact with these histamine receptors.
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Article Synopsis
  • Gut microbes, which are tiny organisms in our intestines, are really important for our health and can influence cancer development.
  • A specific compound called trans-3-indoleacrylic acid (IDA) from a microbe named Peptostreptococcus anaerobius can help colorectal cancer (CRC) grow by affecting certain proteins in our body.
  • The researchers found that targeting the way IDA works could be a new way to treat CRC by stopping the cancer cells from growing.
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Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce α and β subunits. A tethered agonism mediated by the 'Stachel sequence' of the β subunit has been proposed to have central roles in aGPCR activation. Here we present three cryo-electron microscopy structures of aGPCRs coupled to the G heterotrimer.

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Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. These structures revealed that a polar interaction network is essential for catecholamine-like agonist recognition, whereas specific motifs in the extended binding pocket were responsible for discriminating D1- from D2-like receptors.

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Using a ZEISS Axio Scope A1 ordinary polarizing microscope, a ZEISS Sigma 300 scanning electron microscope and a HITACHI S4800 scanning electron microscope, we observe micro/nanocharacteristics of slip planes in gouges sampled from the Tanlu fault zone, the Haiyuan fault zone and several other Late Pleistocene active faults, such as the Haiyang fault, the Shuangshan-Lijiazhuang fault and the Xintai-Mengyin fault, in Shandong Province. Based on microscopic observation of gouges, a straight slip zone is a sign of seismic stick slipping. According to scanning electron microscopy results, the surface of gouges is commonly covered by nanocoatings.

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