Publications by authors named "ChuanNan Zhai"
Myopia is a major public health concern with increasing global prevalence and is the leading cause of vision loss and complications. The potential role of the cornea, a substantial component of refractive power and the protective fortress of the eye, has been underestimated in the development of myopia. Our study acquired corneal stroma tissues from myopic patients undergoing femtosecond laser-assisted small incision lenticule extraction (SMILE) surgery and investigated the differential expression of circulating proteins between subjects with low and high myopia by means of high-throughput proteomic approaches-the quantitative tandem mass tag (TMT) labeling method and parallel reaction monitoring (PRM) validation.
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- The study reviews the association between the SERPINE1 rs1799889 SNP and diabetes mellitus (DM) and its complications, focusing on existing case-control studies up to March 2021.
- Significant findings show that individuals with this SNP have a greater risk of developing DM and related vascular issues, with odds ratios (OR) indicating increased risk across various genetic models.
- The analysis highlights the SNP's specific associations with diabetic retinopathy and nephropathy, emphasizing its relevance particularly in certain populations, like Asians and Europeans.
Background: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that the ubiquitin E3 ligase TRIM21 interacts and ubiquitylates p62 and negatively regulates the p62-Keap1-Nrf2 antioxidant pathway.
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- * A comprehensive review analyzed 58 studies from 2010 to 2019, examining the effectiveness of circulating miRNAs in diagnosing AMI with an overall pooled sensitivity of 82% and specificity of 87%.
- * Specific panels of miRNAs show even higher diagnostic accuracy, with a three-miRNA panel achieving 91% sensitivity and 87% specificity, highlighting their potential as reliable biomarkers for AMI detection.
Background: Atherosclerosis (AS) is the main cause of myocardial infarction and stroke. Macrophage apoptosis in the early stages can attenuate lesions, while in the late stage it is associated with AS plaque rupture.
Objectives: To explore the effects of miR-124-3p regulation of the p38MAPK signaling pathway via the MEKK3 gene on the apoptosis and proliferation of macrophages in mice with coronary AS.
Article Synopsis
- - Statins have been found beneficial in preventing cardiovascular events, especially in older adults, but their effectiveness in this age group is still debated.
- - A review of 17 trials showed that statins significantly reduced the risk of serious health issues like all-cause mortality and heart problems when used for secondary prevention, while having limited effects in primary prevention.
- - Among different statin medications, intensive atorvastatin showed the most significant benefits for secondary prevention in elderly patients, but overall differences between statins had minimal impact on therapy effectiveness.
Article Synopsis
- * Results show that PCI has a significantly higher risk for serious complications like major adverse cardiac events, cardiac death, and repeat procedures compared to CABG.
- * Ultimately, CABG is deemed more effective for managing complex CAD in diabetic patients, although it may carry a greater risk of stroke during mid-term follow-up.
Objective:: M235T polymorphism of the angiotensinogen (AGT) gene has been linked with cardiovascular disease (CVD). The aim of this meta-analysis was to investigate whether combined evidence supports this association.
Methods:: A systematic search was conducted for studies published up to October 2018 that evaluate the association between AGT M235T polymorphism and risk of CVD.
Background: Previous studies have showed that high-dose statin pretreatment could reduce the incidence of periprocedural myocardial infarction (PMI) in patients undergoing percutaneous coronary intervention (PCI). However, previous analyses have not performed reliable grading of evidence.
Hypothesis: In previous analyses, it supposed that the high-dose statin pretreatment was effective in reduction of the rate of PMI.
Background: The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate whether combined evidence shows the association between ZFHX3 rs7193343 SNP and the risk of AF in various populations.
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