[Synthesis and spectral characterization of 10-hydroxycamptothecin].

10-hydroxycamptothecin was synthesized from camptothecin through oxidation and photo-activation. Grouping and optimizing the reaction conditions were as follows: in the oxidation condition: the reaction time 4 h, the reaction temperature 75 degrees C, the amount of H2O2 48 mL(w(H2O2) = 30%), the amount of HAc 350 mL(based on 0.01 mol CPT); in the photochemical reaction: the solvents V(1,4-dioxane): V(acetonitrile): V(H2O) = 6:2:1, bronsted acid catalyst 98% H2SO4.