Publications by authors named "Chuan-ling Li"
Article Synopsis
- The study aimed to assess the effectiveness and safety of HLX04-O, a new formulation of a biosimilar drug, for treating wet age-related macular degeneration (wAMD) in a phase 1/2 clinical trial.
- The trial involved administering HLX04-O injections to eligible patients every four weeks, with evaluations of both treatment efficacy and any adverse effects conducted monthly.
- One participant showed significant improvement in eye health and vision after six treatment cycles, and no adverse effects were reported, suggesting that HLX04-O is well tolerated; however, further research is needed to validate these findings.
Article Synopsis
- CEGI injection, made from rabbit muscle extract and cattle brain gangliosides, is used as a neuroprotectant for nerve injuries, but more clinical evidence is needed to support its efficacy.
- A study involving 319 patients with acute cerebral infarction in China scrutinized CEGI's effects in a randomized placebo-controlled trial over 14 days.
- Results indicated that patients receiving CEGI had better outcomes and reduced disabilities compared to the placebo group, with particularly significant improvements in those with moderate stroke.
Analysis of risk factors for vascular cognitive impairment in patients with cerebral infarction.
Cell Biochem Biophys
March 2015
Article Synopsis
- - The study explored risk factors for vascular cognitive impairment (VCI) in patients who had a cerebral infarction, analyzing data from 300 participants.
- - Important associations with VCI were found for factors like age, glycosylated hemoglobin, atrial fibrillation, blood pressure, homocysteine, and HS-CRP through single factor analysis.
- - The multivariate logistic regression identified age, glycosylated hemoglobin, blood pressure, homocysteine, and HS-CRP as independent risk factors for VCI, suggesting they can help predict cognitive impairment in these patients.
Article Synopsis
- Rare earth elements (REEs), particularly La(III), positively influence the mitochondrial metabolism of plant cells, which helps promote plant growth, especially in hybrid rice.
- The study used a specific technique to assess mitochondrial function in isolated cells, measuring key parameters like activity recovery rate constant (k) and maximum heat power (P(max)).
- Lower concentrations of La(III) enhanced mitochondrial activity significantly, while higher concentrations (140-150 µg/ml) had detrimental effects, suggesting a complex relationship between La(III) levels and plant metabolism.
Article Synopsis
- - The study used microcalorimetry to analyze heat flux and metabolism in Tetrahymena thermophila BF5, while assessing the effects of lanthanum (La(3+)) and calcium (Ca(2+)).
- - Low concentrations of La(3+) boosted T. thermophila's metabolism, but higher concentrations inhibited it, with an IC(50) value of 7.2 x 10(-4) mol/l; in contrast, Ca(2+) showed no significant metabolic stimulation at low levels, with a much higher IC(50).
- - Morphological changes in T. thermophila were noted under high doses of La(3+) and Ca(2+), which correlated