Publications by authors named "Chuan-li Chen"
One-pot synthesis of structurally diverse sulfurized/selenated 4-aminopyrimidines has been reported -BuOK/KSO-promoted four-component reaction of mixed nitriles and disulfides/diselenides. Mechanistic studies indicate that the reaction proceeds through radical and ionic pathways, and an alkenyl sulfide serves as a key intermediate.
View Article and Find Full Text PDFBackground: Recently, hepatic arterial infusion chemotherapy (HAIC) plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma (uHCC) in China. In the clinic, the hepatic arteries of some patients shrink significantly during this treatment, leading to improved short-term efficacy.
Aim: To investigate the relationship between the shrinkage of hepatic arteries and the short-term effect of HAIC plus lenvatinib treatment.
[The role of myosin light chain kinase in intestinal epithelial barrier dysfunction due to hypoxia].
Zhonghua Shao Shang Za Zhi
February 2009
Article Synopsis
- The study investigates how myosin light chain kinase (MLCK) affects intestinal epithelial barrier dysfunction following hypoxia.
- Hypoxia exposure resulted in reduced transepithelial electrical resistance (TER) and abnormal tight junction protein ZO-1 arrangements in the intestinal monolayers, indicating barrier impairment.
- Treatment with ML-9 significantly improved TER and the structure of tight junctions, suggesting that MLCK plays a crucial role in mediating the effects of hypoxia on intestinal barrier function.
[Effect of hypoxia on hypoxia inducible factor 1alpha (HIF-1alpha) activation in intestinal epithelial cells].
Zhonghua Shao Shang Za Zhi
December 2008
Objective: To investigate the effect of hypoxia on HIF-1alpha activation in intestinal epithelial cells.
Methods: Intestinal epithelial cells were randomly divided into normal control group, hypoxia group and hypoxia plus oligomycin group (oligomycin group). In hypoxia group, the cells were exposed to hypoxia for 1, 2, 6, 12 and 24 h.