Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice.

Background: Macamides, the main active components contained in maca, have attracted increasing attention due to their various bioactivities. In this study, crude macamide extract (CME) and purified macamide extract (PME) were prepared by enzyme-assisted extraction and macroporous resin separation, and the anti-fatigue effects of CME and PME were evaluated in a forced swimming model.

Results: The composition analysis results revealed that both CME and PME mainly contain eight kinds of macamide.