Publications by authors named "Chuan-Rou Deng"
Background: Chronic cerebral ischemia (CCI) is a significant health issue characterized by hypoperfusion due to damage or occlusion of the cerebral or carotid arteries. CCI may lead to progressive cognitive impairment that is considered as a prelude to neurodegenerative diseases, including dementia and Alzheimer's disease (AD). Endothelial progenitor cells (EPCs) have been implicated in vascular repair in ischemic cerebrovascular diseases, primarily by differentiating into endothelial cells (ECs) or through paracrine effects.
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- The primary electrophysiological abnormalities in Parkinson's disease are increased beta oscillations and excessive burst discharges in the subthalamic nucleus (STN), directly linked to locomotor issues.
- In a rat model, while the loss of dopaminergic neurons and STN burst discharges develop quickly after a lesion, beta oscillation changes take longer, reflecting differing timescales in behavioral deficits.
- STN burst discharges appear to be a direct result of dopaminergic depletion, while beta oscillations may represent secondary changes that indicate subtler cortical dysfunctions in Parkinson's disease.
Objective: This study examines the effect of Dextromethorphan (d-3-methoxy-17-methylmorphinan; DXM), a commonly used cough-suppressing drug, on the expression of VCAM-1 and ICAM-1 in human umbilical vein endothelial cells (HUVECs) stimulated with lipopolysaccharide (LPS).
Methods: The effect of DXM on expression of cell adhesion molecules induced by LPS was evaluated by monocyte bindings in vitro and ex vivo and transmigration assays. The signaling pathways involved in the inflammation inhibitory effect of DXM were analyzed by Western blot and immunofluorescent stain.