Publications by authors named "Chuan-Qin Xu"
Valproic acid (VPA) has been suggested to be a histone deacetylase inhibitor (HDACI). Our present study revealed that VPA at 1 mm, which had no effect on cell proliferation, can significantly increase the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP). VPA treatment markedly decreased the mRNA and protein levels of ABCA1, while had no significant effect on ABCA3, ABCA7 or ABCB10.
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- Obesity worsens asthma control due to various factors, including increased airway neutrophils and comorbidities like sleep apnea and depression, and IL-17 may play a role in these effects.
- In a study of both stable and acute asthma patients, researchers found that obese subjects had higher IL-17 levels and airway neutrophilia, with these factors linked to depressive symptoms.
- While IL-17 levels were higher in acute asthma patients compared to stable ones, overall effects of obesity on acute asthma remain unclear, suggesting that IL-17 contributes to poor disease control in obese asthmatics.
Background: The objective of this observational study was to determine whether there is an association between extubation success and uric acid in chronic obstructive pulmonary disease patients with mechanical ventilation admitted to the intensive care units, and identify the risk markers for extubation success in COPD patients with mechanical ventilation.
Methods: Consecutive COPD patients with intubation were screened at baseline. The study included patients on mechanical ventilation (MV) for over 12 hours and who, in the process of weaning, were subjected to low-level pressure support.
Introduction: The role of inflammation and immunity in COPD treatment is increasingly being recognized. The relationship between anti-inflammation/immunoregulation and emphysema in COPD lungs remains to be elucidated. The aim of this study was to investigate the effects of azithromycin (Azm) on the development of emphysema in smoking-induced COPD in rats.
View Article and Find Full Text PDFBackground And Aims: The objective of this observational study was to determine whether there is an association between atrial fibrillation (AF) and uric acid and to identify the risk markers for AF in obstructive sleep apnea (OSA).
Methods: Consecutive patients with newly diagnosed OSA were screened at baseline. The final study population consisted of 516 patients.
Article Synopsis
- Acinetobacter baumannii is a resilient, gram-negative bacterium that poses a significant threat in healthcare settings due to its rapid development of antibiotic resistance, particularly to carbapenems.
- A study analyzed data from a large hospital to identify risk factors associated with pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB) compared to carbapenem-susceptible strains (CSAB).
- Findings revealed that patients with CRAB pneumonia had a higher mortality rate, with specific risk factors including high APACHE II scores, chronic health issues, use of invasive devices, and prior antibiotic use within 28 days.
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults.
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