Publications by authors named "Chuan-Hua Zhan"
Diagnostic Value of a Combined Serum α-Hydroxybutyrate Dehydrogenase, Carcinoembryonic Antigen and Glycoantigen 125 Test for Early-Stage Breast Cancer.
Breast Cancer (Dove Med Press)
August 2023
Article Synopsis
- - The study aimed to evaluate the effectiveness of measuring serum levels of α-hydroxybutyrate dehydrogenase (α-HBDH), carcinoembryonic antigen (CEA), and cancer antigen 125 (CA125) for diagnosing early-stage breast cancer (ESBC) compared to benign breast disease and healthy controls.
- - Results showed that patients with ESBC had significantly higher levels of these markers, and using a combined approach for detection improved the diagnostic rate notably, with a combined detection sensitivity of 54.5% and specificity of 91.2%.
- - The overall conclusion is that measuring α-HBDH, CEA, and CA125 together offers a more reliable diagnostic tool for early-stage breast cancer
The cancer-testis antigen A-kinase anchor protein 3 (AKAP3) has been shown to have a strong association with breast cancer (BC). However, its role in BC progression received scant attention. We aimed to explore the prognostic implication of aberrant AKAP3 expression for a better knowledge of BC progression and improved treatment.
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